At a crossroads of cancer risk and aging: the role of telomeres
The risk of overall cancer inevitably increases with advancing age. The cancer incidence rate is not constant within the human life span (it exponentially increases with advancing age). Aging itself is a complex biological process with a poorly understood mechanism of its regulation. The aging proce...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2010 |
| Автор: | |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2010
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| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/32299 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | At a crossroads of cancer risk and aging: the role of telomeres / B.I. Gerashchenko // Experimental Oncology. — 2010. — Т. 32, № 4. — С. 224–227. — Біліогр.: 42 назв. — англ. |
Репозитарії
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nasplib_isofts_kiev_ua-123456789-32299 |
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Gerashchenko, B.I. 2012-04-16T16:26:04Z 2012-04-16T16:26:04Z 2010 At a crossroads of cancer risk and aging: the role of telomeres / B.I. Gerashchenko // Experimental Oncology. — 2010. — Т. 32, № 4. — С. 224–227. — Біліогр.: 42 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/32299 The risk of overall cancer inevitably increases with advancing age. The cancer incidence rate is not constant within the human life span (it exponentially increases with advancing age). Aging itself is a complex biological process with a poorly understood mechanism of its regulation. The aging process, as evidenced from the survey of the chances for death for the large cohort of people of various age groups, manifests probably due to a progressive accumulation of diverse adverse changes that increase the risk of death. While an increase of cancer risk due to aging cannot be fully explained, the length of telomeres (biomarker of aging) appears to be important to predict this risk. Cellular senescence, which is believed to be associated with dysfunctional (shortened) telomeres, may contribute to the aging of a whole organism. Here, based on recent literature data, we investigate the possible link between telomere dysfunction associated cellular senescence and tumorigenesis. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews At a crossroads of cancer risk and aging: the role of telomeres Article published earlier |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
At a crossroads of cancer risk and aging: the role of telomeres |
| spellingShingle |
At a crossroads of cancer risk and aging: the role of telomeres Gerashchenko, B.I. Reviews |
| title_short |
At a crossroads of cancer risk and aging: the role of telomeres |
| title_full |
At a crossroads of cancer risk and aging: the role of telomeres |
| title_fullStr |
At a crossroads of cancer risk and aging: the role of telomeres |
| title_full_unstemmed |
At a crossroads of cancer risk and aging: the role of telomeres |
| title_sort |
at a crossroads of cancer risk and aging: the role of telomeres |
| author |
Gerashchenko, B.I. |
| author_facet |
Gerashchenko, B.I. |
| topic |
Reviews |
| topic_facet |
Reviews |
| publishDate |
2010 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
The risk of overall cancer inevitably increases with advancing age. The cancer incidence rate is not constant within the human life span (it exponentially increases with advancing age). Aging itself is a complex biological process with a poorly understood mechanism of its regulation. The aging process, as evidenced from the survey of the chances for death for the large cohort of people of various age groups, manifests probably due to a progressive accumulation of diverse adverse changes that increase the risk of death. While an increase of cancer risk due to aging cannot be fully explained, the length of telomeres (biomarker of aging) appears to be important to predict this risk. Cellular senescence, which is believed to be associated with dysfunctional (shortened) telomeres, may contribute to the aging of a whole organism. Here, based on recent literature data, we investigate the possible link between telomere dysfunction associated cellular senescence and tumorigenesis.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/32299 |
| citation_txt |
At a crossroads of cancer risk and aging: the role of telomeres / B.I. Gerashchenko // Experimental Oncology. — 2010. — Т. 32, № 4. — С. 224–227. — Біліогр.: 42 назв. — англ. |
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