Химиотерапия взрослых больных с саркомами мягких тканей

В обзоре рассмотрены общие принципы цитостатического лечения взрослых больных с саркомами мягких тканей. Роль химиотерапии при этом заболевании на протяжении последних лет повышается. Hаиболее эффективными цитостатиками являются доксорубицин и ифосфамид, причем у обоих препаратов установлена зависим...

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Бібліографічні деталі
Опубліковано в: :Онкологія
Дата:2000
Автор: Шпарик, Я.В.
Формат: Стаття
Мова:Російська
Опубліковано: Iнститут експериментальної патології, онкології і радіобіології ім. Р. Є. Кавецького 2000
Теми:
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/32929
Теги: Додати тег
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Химиотерапия взрослых больных с саркомами мягких тканей / Я.В. Шпарик // Онкологія. — 2000. — Т. 2, № 1. — С. 126-132. — Бібліогр.: 96 назв. — рос.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
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author Шпарик, Я.В.
author_facet Шпарик, Я.В.
citation_txt Химиотерапия взрослых больных с саркомами мягких тканей / Я.В. Шпарик // Онкологія. — 2000. — Т. 2, № 1. — С. 126-132. — Бібліогр.: 96 назв. — рос.
collection DSpace DC
container_title Онкологія
description В обзоре рассмотрены общие принципы цитостатического лечения взрослых больных с саркомами мягких тканей. Роль химиотерапии при этом заболевании на протяжении последних лет повышается. Hаиболее эффективными цитостатиками являются доксорубицин и ифосфамид, причем у обоих препаратов установлена зависимость эффективности от дозы. Химиотерапию применяют как элемент радикального комбинированного лечения, а также как паллиативный метод при метастатическом процессе. При рабдомиосаркоме химиотерапия эффективна практически при любой стадии заболевания. Chemotherapy has an increasing role in the therapy of soft tissue sarcomas. Meanwhile, chemotherapy of these tumors is frequently considered in general without taking into account the peculiar clinical features of various subtypes. Doxorubicin and ifosfamide are the most active drugs in the treatment of soft tissue sarcomas. Chemotherapy could be used both for radical and for palliative treatment. For rhabdomyosarcoma, chemotherapy is effective in all the stages of such disease.
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fulltext Ê Î Ð Ï Î Ð À Ò È Â Í À ß È Í Ô Î Ð Ì À Ö È ß ÎÍÊÎËÎÃÈß � Ò. 2 � ¹ 1�2 � 2000126 Ñàðêîìû ìÿãêèõ òêàíåé (ÑÌÒ) �îòíîñèòåëü- íî ðåäêèé òèï îïóõîëåé, äëÿ êîòîðîãî õàðàêòåð- íî çíà÷èòåëüíîå àíàòîìè÷åñêîå è ãèñòîëîãè÷åñ- êîå ðàçíîîáðàçèå. Ó âçðîñëûõ ÑÌÒ ñîñòàâëÿþò ìåíåå 1%, ó äåòåé � 7% âñåõ çëîêà÷åñòâåííûõ îïóõîëåé. Âî Ëüâîâñêîé îáëàñòè â 1999 ã. çàðåãè- ñòðèðîâàíî 58 ñëó÷àåâ ÑÌÒ (0,8% îò 7072 ïåð- âè÷íûõ îíêîëîãè÷åñêèõ áîëüíûõ). Ñðåäè çàáîëåâ- øèõ áûëî 2 (3,4%) äåòåé. Ïðåäïîëàãàåòñÿ, ÷òî â ÑØÀ â 2000 ã. ÑÌÒ çàáîëåþò 8100 ÷åëîâåê (îêî- ëî 2 ñëó÷àåâ íà 100 000 íàñåëåíèÿ), à óìðóò îò ýòîé ïàòîëîãèè 4600 [50]. Håñêîëüêî ÷àùå áîëåþò ìóæ- ÷èíû. Ðàñïðåäåëåíèå çàáîëåâøèõ ïî âîçðàñòó òà- êîâî: ìîëîæå 40 ëåò � 20%, 40�60 ëåò � 28%, ñòàð- øå 60 ëåò � 52% áîëüíûõ [76]. Îïðåäåëåíèå ñòàäèè ÑÌÒ çàâèñèò îò ãèñòîëî- ãè÷åñêîé ñòðóêòóðû, ñòåïåíè çëîêà÷åñòâåííîñòè, ðàçìåðîâ ïåðâè÷íîé îïóõîëè, íàëè÷èÿ èëè îòñóò- ñòâèÿ îòäàëåííûõ ìåòàñòàçîâ. Õîòÿ äî ñèõ ïîð íåò ñòàíäàðòèçèðîâàííîé îáùåïðèíÿòîé ñèñòåìû îïðåäåëåíèÿ ñòåïåíè çëîêà÷åñòâåííîñòè ÑÌÒ, áîëüøèíñòâî ïàòîëîãîâ ñõîäÿòñÿ âî ìíåíèè, ÷òî íàèáîëåå âàæíûìè êðèòåðèÿìè ÿâëÿþòñÿ äèôôå- ðåíöèàöèÿ è âàñêóëÿðèçàöèÿ îïóõîëè, íàëè÷èå íåêðîçîâ, êîëè÷åñòâî ìèòîçîâ. Îáû÷íî ÑÌÒ èìåþò êëèíè÷åñêè áåññèìïòîì- íîå òå÷åíèå. Ðåêîìåíäóþò ïðîâîäèòü áèîïñèþ äëèòåëüíî ñóùåñòâóþùåé (áîëåå 4 íåä) îïóõîëè ìÿãêèõ òêàíåé ðàçìåðîì áîëåå 5 ñì.  ñâÿçè ñ îò- íîñèòåëüíî ðåäêîé âûÿâëÿåìîñòüþ ÑÌÒ îòñóò- ñòâóþò îïòèìàëüíûå îáùåïðèíÿòûå ñòàíäàðòû ëå÷åíèÿ ýòîãî çàáîëåâàíèÿ ó âçðîñëûõ. Îäíàêî îñíîâíûì ìåòîäîì ëå÷åíèÿ ÿâëÿåòñÿ õèðóðãè÷åñ- êîå óäàëåíèå îïóõîëè (òàáë. 1). Õèìèîòåðàïèþ (ÕÒ) � àäúþâàíòíóþ è íåî- àäúþâàíòíóþ � ïðèìåíÿþò êàê â ðåæèìå ðàäè- êàëüíîãî ëå÷åíèÿ áîëüíîãî ñ ÑÌÒ, òàê è â êà÷å- ñòâå ïàëëèàòèâíîãî ìåòîäà. Ïàëëèàòèâíàÿ ÕÒ. Ïðè ïðîâåäåíèè ìîíîõèìè- îòåðàïèè ðàñïðîñòðàíåííûõ ÑÌÒ íàèáîëåå àêòèâ- íûìè ïðåïàðàòàìè ÿâëÿþòñÿ èôîñôàìèä (òàáë. 2) è äîêñîðóáèöèí (òàáë. 3), ýôôåêòèâíîñòü êîòîðûõ ïðåâûøàåò 20%. Ïî ñâîäíûì ìíîãîëåòíèì äàííûì EORTC (1742 ïàöèåíòà), 5-ëåòíÿÿ âûæèâàåìîñòü áîëüíûõ ïîñëå ÕÒ äîêñîðóáèöèíîì ñîñòàâèëà 8,6% [14]. ×òî êàñàåòñÿ àêòèâíîñòè èôîñôàìèäà, òî óñ- òàíîâëåíî, ÷òî ýòîò öèòîñòàòèê îòíîñèòåëüíî ýô- ôåêòèâåí ó 16% áîëüíûõ, êîòîðûå óæå ïîëó÷àëè ïàëëèàòèâíóþ ÕÒ äîêñîðóáèöèíîì [61]. Î÷åíü âàæíûì êàê ñ òåîðåòè÷åñêîé, òàê è ñ ïðàêòè÷åñ- ß.Â. Øïàðèê Ëüâîâñêèé ãîñóäàðñòâåííûé îíêîëîãè÷åñêèé ðåãèîíàëüíûé ëå÷åáíî-äèàãíîñòè÷åñêèé öåíòð, Ëüâîâ, Óêðàèíà Ëüâîâñêèé ãîñóäàðñòâåííûé ìåäèöèíñêèé óíèâåðñèòåò èì. Äàíèëà Ãàëèöêîãî, Ëüâîâ, Óêðàèíà Êëþ÷åâûå ñëîâà: õèìèîòåðàïèÿ, ñàðêîìû ìÿãêèõ òêàíåé, âçðîñëûå. ÕÈÌÈÎÒÅÐÀÏÈß ÂÇÐÎÑËÛÕ ÁÎËÜÍÛÕ Ñ ÑÀÐÊÎÌÀÌÈ ÌßÃÊÈÕ ÒÊÀÍÅÉ Ðåçþìå.  îáçîðå ðàññìîòðåíû îáùèå ïðèíöèïû öèòîñòàòè÷åñêîãî ëå- ÷åíèÿ âçðîñëûõ áîëüíûõ ñ ñàðêîìàìè ìÿãêèõ òêàíåé. Ðîëü õèìèîòåðà- ïèè ïðè ýòîì çàáîëåâàíèè íà ïðîòÿæåíèè ïîñëåäíèõ ëåò ïîâûøàåòñÿ. Hàèáîëåå ýôôåêòèâíûìè öèòîñòàòèêàìè ÿâëÿþòñÿ äîêñîðóáèöèí è èôîñôàìèä, ïðè÷åì ó îáîèõ ïðåïàðàòîâ óñòàíîâëåíà çàâèñèìîñòü ýô- ôåêòèâíîñòè îò äîçû. Õèìèîòåðàïèþ ïðèìåíÿþò êàê ýëåìåíò ðàäè- êàëüíîãî êîìáèíèðîâàííîãî ëå÷åíèÿ, à òàêæå êàê ïàëëèàòèâíûé ìå- òîä ïðè ìåòàñòàòè÷åñêîì ïðîöåññå. Ïðè ðàáäîìèîñàðêîìå õèìèîòå- ðàïèÿ ýôôåêòèâíà ïðàêòè÷åñêè ïðè ëþáîé ñòàäèè çàáîëåâàíèÿ. Òàáëèöà 1 Êëèíè÷åñêèå ïîäõîäû ê ëå÷åíèþ áîëüíûõ ñ ÑÌÒ Ìåòîä Ãèñòîëîãè÷åñêàÿ ñòåïåíü çëîêà÷åñòâåííîñòè ëå÷åíèÿ Äîáðîêà÷åñòâåííûå Hèçêàÿ Ñðåäíÿÿ Âûñîêàÿ Îïåðàöèÿ + + + + Îáëó÷åíèå - ± + + Õèìèîòåðàïèÿ - - - +* 5-ëåòíÿÿ âûæèâàåìîñòü îïåðèðîâàííûõ áîëüíûõ 100% 90% 80% 40�50% *Õèìèîòåðàïèþ ïðèìåíÿþò ïðè ëèïîñàðêîìàõ âûñîêîé ñòåïåíè çëîêà÷åñòâåííîñòè, çëîêà÷åñòâåííûõ ôèáðîçíûõ ãèñòèîöèòîìàõ, ñèíîâèàëüíûõ ñàðêîìàõ, íåéðîñàðêîìàõ è àíãèîñàðêîìàõ. Òàáëèöà 2 Ýôôåêòèâíîñòü ÕÒ èôîñôàìèäîì ïðè ðàñïðîñòðàíåííûõ ôîðìàõ ÑÌÒ Èñòî÷- íèê Äîçà èôîñôàìèäà è äëè- òåëüíîñòü ââåäåíèÿ (äíåé) Êîëè÷åñòâî áîëüíûõ Îáùàÿ ýôôåê- òèâíîñòü (%) [39] 2,5�4,5 ã/ì 2 â ñóòêè (4 äíÿ) 20 35 [54] 2,5�3,5 ã/ì 2 â ñóòêè (5 äíåé) 11 36 [68] 2,5 ã/ì 2 â ñóòêè (5 äíåé) 16 31 [33] 1,25�2,5 ã/ì 2 â ñóòêè (5 äíåé) 13 38 [30] 2 ã/ì 2 â ñóòêè (6 äíåé) 28 39 [63] 1,8 ã/ì 2 â ñóòêè (5 äíåé) 18 22 [7] 2�2,5 ã/ì 2 â ñóòêè (4 äíÿ) 108 23 [88] 5�8 ã/ì 2 â ñóòêè (1 äåíü) 40 38 [19] 5 ã/ì 2 â ñóòêè (1 äåíü) 68 18 [57] 4 ã/ì 2 â ñóòêè (3 äíÿ) 36 33 [12] 2 ã/ì 2 â ñóòêè (7 äíåé) 45 17 [72] 5 ã/ì 2 â ñóòêè (1 äåíü) 50 3 [72] 3 ã/ì 2 â ñóòêè (3 äíÿ) 51 18 [74] 3,5 ã/ì 2 â ñóòêè (4 äíÿ) 38 39 [23] 2 ã/ì 2 â ñóòêè (7 äíåé) 48 38 Òàáëèöà 3 Ýôôåêòèâíîñòü ÕÒ äîêñîðóáèöèíîì ïðè ðàñïðîñòðàíåííûõ ôîðìàõ ÑÌÒ Èñòî÷- íèê Äîçà äîêñîðóáèöèíà è ïåðèîäè÷íîñòü ïðèìåíåíèÿ Êîëè÷åñòâî áîëüíûõ Îáùàÿ ýôôåê- òèâíîñòü (%) [16] 60�90 ìã/ì 2 êàæäûå 3 íåä 130 34 [69] 25�70 ìã/ì 2 êàæäûå 3 íåä 82 28 [70] 60�75 ìã/ì 2 êàæäûå 3 íåä 49 31 [83] 70 ìã/ì 2 êàæäûå 3 íåä 66 27 [17] 70 ìã/ì 2 êàæäûå 3 íåä 93 19 [17] 15 ìã/ì 2 åæåíåäåëüíî 92 16 [32] 20�25 ìã/ì 2 êàæäûå 3 íåä 15 13 [67] 75 ìã/ì 2 êàæäûå 3 íåä 83 25 ÎÍÊÎËÎÃÈß � Ò. 2 � ¹ 1�2 � 2000 127 Ê Î Ð Ï Î Ð À Ò È Â Í À ß È Í Ô Î Ð Ì À Ö È ß êîé òî÷êè çðåíèÿ ÿâëÿåòñÿ ïîäòâåðæäåíèå ÷åòêîé çàâèñèìîñòè ýôôåêòèâíîñòè äîêñîðóáèöèíà è èôîñôàìèäà îò äîçû. Ýòî ñîãëàñóåòñÿ ñ äàííûìè îòäåëåíèÿ õèìèîòåðàïèè íàøåãî îíêîöåíòðà: çà ïîñëåäíèå 5 ëåò ïðîâåäåíî ëå÷åíèå 22 áîëüíûõ ÑÌÒ. Ó 3 èç íèõ äîñòèãíóòà ÷àñòè÷íàÿ ðåãðåññèÿ îïóõîëè. Ýòè áîëüíûå ïîëó÷àëè äîêñîðóáèöèí â äîçå íå íèæå 70 ìã/ì2, à 2 èç íèõ � êðîìå òîãî, èôîñôàìèä â îáùåé äîçå íå íèæå 6 ã/ì2. Hà äîçî- çàâèñèìîñòè ýôôåêòà îñíîâàíû ïðîâîäèìûå â íà- ñòîÿùåå âðåìÿ èññëåäîâàíèÿ âûñîêîäîçîâîé ÕÒ ñ ïåðåñàäêîé êîñòíîãî ìîçãà ïðè ÑÌÒ [41, 92]. Äðóãèå öèòîñòàòèêè ÿâëÿþòñÿ ýôôåêòèâíûìè ìåíåå ÷åì ó 20% áîëüíûõ. Ñðåäè íèõ äàêàðáàçèí (15�20%) [24], öèêëîôîñôàìèä (8%) [19], ìåòîòðåê- ñàò (15�20%) [4, 89], âèíêðèñòèí (12%) [55, 85], öèñïëàòèí (10�15%) [22, 44, 90], êàðáîïëàòèí (12%) [49].  íàñòîÿùåå âðåìÿ èçó÷àåòñÿ êëèíè÷åñêàÿ ðîëü íîâûõ öèòîñòàòèêîâ � ïàêëèòàêñåëà [10, 28], äîöå- òàêñåëà [34, 51], òîïîòåêàíà [21], ãåìöèòàáèíà [3, 66], ðàëòèòðèêñåäà [15] è ò.ä. Îäíàêî èõ àêòèâíîñòü, ïî ïðåäâàðèòåëüíûì äàííûì, íå ïðåâûøàåò àêòèâ- íîñòü äîêñîðóáèöèíà è èôîñôàìèäà. Hà ïðàêòèêå ìîíîõèìèîòåðàïèþ ðåêîìåíäó- þò ïðèìåíÿòü òîëüêî ïðè ïàëëèàòèâíîì ëå÷åíèè. Îïòèìàëüíîé äîçîé äîêñîðóáèöèíà ÿâëÿåòñÿ 60� 90 ìã/ì2 â êà÷åñòâå 48�96-÷àñîâûõ èíôóçèé (â öåëÿõ ñíèæåíèÿ ðèñêà êàðäèîòîêñè÷íîñòè) êàæ- äûå 3 íåä [26]. Èôîñôàìèä áîëåå àêòèâåí ïðè ïðîâåäåíèè êîðîòêèõ èíôóçèé (îò 1 äî 4 ÷) ïî ñðàâíåíèþ ñ äëèòåëüíûìè.  ýòîì ñëó÷àå åãî ýô- ôåêòèâíîñòü òàêàÿ æå, êàê äîêñîðóáèöèíà [8]. Ðåêîìåíäóåìàÿ äîçà èôîñôàìèäà � 8�14 ã/ì2 â òå÷åíèå 4�5 äíåé. Ýôôåêòèâíîñòü èôîñôàìèäà â òàêèõ äîçàõ ïðèáëèçèòåëüíî îäèíàêîâà â êà÷åñòâå ïåðâîé è âòîðîé (ïîñëå ÕÒ äîêñîðóáèöèíîì) ëè- íèè ëå÷åíèÿ. Èôîñôàìèä â áîëåå âûñîêèõ äîçàõ ýôôåêòèâåí ïî÷òè ó 30% áîëüíûõ, äàæå ïðè ðå- çèñòåíòíîñòè îïóõîëè ê åãî äåéñòâèþ â íèçêèõ äîçàõ [57]. Ïðè ñðàâíåíèè ýôôåêòèâíîñòè öèêëî- ôîñôàìèäà è èôîñôàìèäà (èññëåäîâàíèå EORTC) óñòàíîâëåíî, ÷òî ýôôåêòèâíîñòü èôîñôàìèäà âûøå [19].  íàñòîÿùåå âðåìÿ EORTC ïðîâîäèò ñðàâíèòåëüíîå ðàíäîìèçèðîâàííîå èññëåäîâàíèå àêòèâíîñòè èôîñôàìèäà è äîêñîðóáèöèíà â ðàç- ëè÷íûõ äîçàõ (ïëàíèðóåòñÿ îõâàòèòü íå ìåíåå 780 áîëüíûõ) [52]. Ó÷èòûâàÿ, ÷òî äîêñîðóáèöèí è èôîñôàìèä � íàèáîëåå àêòèâíûå öèòîñòàòèêè, êëèíèöèñòû èç ìíîãèõ îíêîëîãè÷åñêèõ öåíòðîâ èññëåäóþò ýôôåê- òèâíîñòü èõ êîìáèíàöèè â ðàçíûõ äîçàõ ïðè ïàë- ëèàòèâíîé ÕÒ ïî ïîâîäó ÑÌÒ (òàáë. 4). ×àùå ðå- êîìåíäóþò ïðèìåíÿòü äîêñîðóáèöèí â äîçå 60� 90 ìã/ì2, èôîñôàìèä � â äîçå 5�10 ã/ì2 íà ïðîòÿæåíèè 3�5 äíåé. Ýôôåêòèâíîñòü òàêîãî ëå÷å- íèÿ ñîñòàâëÿåò 35�65%. Îäíàêî ïðè ýòîì äîâîëü- íî âûñîêà åãî îáùàÿ òîêñè÷íîñòü. Ïîêà íåò åäè- íîãî ìíåíèÿ, ïîâûøàåòñÿ ëè ýôôåêòèâíîñòü êîìáèíèðîâàííîé ÕÒ ïðè äîïîëíèòåëüíîì èñïîëüçîâàíèè äàêàðáàçèíà. Èòàëüÿíñêèå îíêîëî- ãè â êîìáèíàöèè ñ èôîñôàìèäîì âìåñòî äîêñîðó- áèöèíà ñ óñïåõîì ïðèìåíÿþò ýïèðóáèöèí [42]. Íà ïðîòÿæåíèè ïîñëåäíèõ ëåò àêòèâíî èçó÷àþò ýô- ôåêòèâíîñòü êîìáèíàöèè MAID (òàáë. 5) [25, 31, 38]. Ðåçóëüòàòû ëå÷åíèÿ äåòåé ñ ÑÌÒ ñóùåñòâåí- íî óëó÷øèëèñü ïîñëå çàìåíû êîìáèíàöèè VACA íà VAIA (âèíêðèñòèí + äîêñîðóáèöèí + öèêëî- ôîñôàìèä/èôîñôàìèä + àêòèíîìèöèí D) � 5-ëåò- íÿÿ âûæèâàåìîñòü ïîâûñèëàñü ñ 44 äî 60% [56]. Åñëè îáîáùèòü ìíîãî÷èñëåííûå ðåçóëüòàòû ïðîâåäåíèÿ ïàëëèàòèâíîé ÕÒ ïðè ÑÌÒ, òî îêà- æåòñÿ, ÷òî ýôôåêòèâíîñòü ìîíîòåðàïèè ñîñòàâ- ëÿåò 15�30%, à êîìáèíèðîâàííîé � 20�50%. Îä- íàêî ïîëíàÿ ðåãðåññèÿ îïóõîëè íàáëþäàåòñÿ äî- âîëüíî ðåäêî. Êðîìå òîãî, ìíîãèå êëèíèöèñòû îòðèöàþò âëèÿíèå êîìáèíèðîâàííîé ÕÒ íà ïî- êàçàòåëè äëèòåëüíîé âûæèâàåìîñòè (òàáë. 6). Óñ- òàíîâëåíî, ÷òî ïðîâåäåíèå ÕÒ ïîñëå íåóäà÷è ëå- ÷åíèÿ äîêñîðóáèöèíîì è/èëè èôîñôàìèäîì íå- öåëåñîîáðàçíî. Îäíàêî, êàê óêàçûâàëîñü ðàíåå, èôîñôàìèä â âûñîêèõ äîçàõ ýôôåêòèâåí ó òåõ áîëüíûõ, êîòîðûå ïåðåä ýòèì ïîëó÷àëè èôîñôà- ìèä èëè äîêñîðóáèöèí â íèçêèõ äîçàõ. Àäúþâàíòíàÿ ÕÒ.  íà÷àëå 70-õ ãîäîâ óñòàíîâ- ëåíà ýôôåêòèâíîñòü àäúþâàíòíîé ÕÒ ïðè ðàêå ìîëî÷íîé æåëåçû è îñòåîñàðêîìå. Ýòî ñòàëî òåî- ðåòè÷åñêèì îáîñíîâàíèåì äëÿ ïðèìåíåíèÿ ýòîãî ìåòîäà ó áîëüíûõ ñ ÑÌÒ, ïðè êîòîðûõ ïðîãðåñ- ñèðîâàíèå çàáîëåâàíèÿ è ñìåðòü ïîñëå ðàäèêàëü- íîãî ëå÷åíèÿ îáóñëîâëåíû â áîëüøèíñòâå ñëó÷à- åâ íàëè÷èåì îòäàëåííûõ ìåòàñòàçîâ.  òàáë. 7 ïðåäñòàâëåíû äàííûå ðàíäîìèçèðîâàííûõ èññëå- äîâàíèé àäúþâàíòíîé ÕÒ ïðè ÑÌÒ. Òàáëèöà 4 Ýôôåêòèâíîñòü ÕÒ êîìáèíàöèåé äîêñîðóáèöèíà (èëè ýïèðóáèöèíà*) è èôîñôàìèäà ïðè ðàñïðîñòðàíåííûõ ôîðìàõ ÑÌÒ Èñòî÷- íèê Äîêñîðóáè- öèí (ìã/ì 2 ) Èôîñôà- ìèä (ã/ì 2 ) Êîëè÷åñòâî áîëüíûõ Ýôôåêòèâ- íîñòü (%)  òîì ÷èñëå ïîë- íûõ ðåãðåññèé (%) [64] 40 5 28 7 1 [64] 60 5 22 41 2 [84] 50 5 175 35 15 [58] 60 5 42 36 3 [94] 60 10 44 43 6 [87] 75 5 104 45 10 [92] 50 5 134 20 4 [92] 75 5 128 21 2 [11] 60 7,5 40 38 15 [60] 90 10 31 55 13 [62] 50 12 56 31 - [73] 110* 10 39 59 13 [79] 90* 12,5 46 52 22 Òàáëèöà 5 Âàðèàíòû êîìáèíàöèè MAID â ëå÷åíèè áîëüíûõ ÑÌÒ Ñõåìà I âàðèàíò** II âàðèàíò*** MAID* Äîçû ïðåïàðàòîâ â ìã/ì 2 , â/â Èôîñôàìèä 6000 (ñ 1-ãî ïî 3-é äåíü öèêëà) 7500 (1-é äåíü) Ìåñíà 10 000 (ñ 1-ãî ïî 4-é äåíü öèêëà) 7500 (1-é äåíü) Äîêñîðóáèöèí 60 (ñ 1-ãî ïî 4-é äåíü öèêëà) 60 (1-é äåíü) Äàêàðáàçèí 1000 (ñ 1-ãî ïî 4-é äåíü öèêëà) 900 (1-é äåíü) * Ïðèìåíÿþò êàæäûå 3 íåä. ** Ïðèâåäåíû ñóììàðíûå äîçû öèòîñòàòèêîâ, êîòîðûå ââîäÿò ìåòîäîì íåïðåðûâíîé â/â èíôóçèè. *** Öèòîñòàòèêè ââîäÿò ïóòåì êðàòêîâðåìåííîé â/â èíôóçèè. Ê Î Ð Ï Î Ð À Ò È Â Í À ß È Í Ô Î Ð Ì À Ö È ß ÎÍÊÎËÎÃÈß � Ò. 2 � ¹ 1�2 � 2000128 Èññëåäîâàòåëè èç Áîðäî, à òàêæå èç Îðòîïåäè- ÷åñêîãî èíñòèòóòà Rizzoli (Áîëîíüÿ) äîñòèãëè äî- ñòîâåðíîãî óëó÷øåíèÿ ïîêàçàòåëåé äëèòåëüíîé âû- æèâàåìîñòè ïîñëå àäúþâàíòíîé ÕÒ ïî ñõåìå CyVADIC, äîêñîðóáèöèíîì [45, 78] èëè êîìáèíà- öèåé ýïèðóáèöèíà è èôîñôàìèäà [43] ñîîòâåò- ñòâåííî. Ñëåäóåò ó÷èòûâàòü çíà÷èòåëüíûå ðàçëè- ÷èÿ ìåæäó ãðóïïàìè áîëüíûõ â çàâèñèìîñòè îò ëîêàëèçàöèè è ãèñòîëîãè÷åñêîãî òèïà îïóõîëè â êàæäîì èññëåäîâàíèè. Êðîìå òîãî, â áîëüøèíñòâå ðàíäîìèçèðîâàííûõ èññëåäîâàíèé ïðîâîäèëè òîëüêî ìîíîòåðàïèþ äîêñîðóáèöèíîì â ñóáîïòè- ìàëüíûõ äîçàõ. Ïóáëèêàöèé î ðåçóëüòàòàõ ðàíäî- ìèçèðîâàííûõ èññëåäîâàíèé ïðèìåíåíèÿ êîì- áèíàöèè äîêñîðóáèöèíà è èôîñôàìèäà â îïòè- ìàëüíûõ äîçàõ, à òàêæå êîìáèíàöèè MAID íåäîñòàòî÷íî. Hå èñêëþ÷åíî, ÷òî òàêîå ëå÷åíèå áûëî áû áîëåå ýôôåêòèâíûì.  ÷àñòíîñòè, ñîãëàñ- íî ïðåäâàðèòåëüíûì äàííûì èòàëüÿíñêèõ îíêî- ëîãîâ, àäúþâàíòíàÿ ÕÒ ýïèðóáèöèíîì (ïî 60 ìã/ì2 2 äíÿ ïîäðÿä) è èôîñôàìèäîì (ïî 1,8 ã/ì2 5 äíåé ïîäðÿä) ïîä çàùèòîé êîëîíèåñòèìóëèðóþùåãî ôàêòîðà (G-CSF ïî 300 ìêã/äåíü) ïîçâîëèëà ñó- ùåñòâåííî óëó÷øèòü ïîêàçàòåëè âûæèâàåìîñòè áîëüíûõ ïîñëå îïåðàòèâíîãî âìåøàòåëüñòâà [43]. Håñêîëüêî ãðóïï êëèíèöèñòîâ ïðîâåëè ìåòà- àíàëèç îïóáëèêîâàííûõ ðåçóëüòàòîâ ðàíäîìèçè- ðîâàííûõ èññëåäîâàíèé. Òàê, ïî äàííûì 11 èñ- ñëåäîâàíèé, êîòîðûå ïðîâåëè M.M. Zalupski è ñî- àâòîðû [96], äëèòåëüíàÿ âûæèâàåìîñòü ïîñëå àäúþâàíòíîé ÕÒ ÑÌÒ ïîâûñèëàñü ñ 71 äî 81% (ð = 0,0005), à áåçðåöèäèâíàÿ âûæèâàåìîñòü � ñ 53 äî 68% (ð = 0,00001) [96]. J.F. Tierney è ñîàâòî- ðû [91], êîòîðûå ïðîàíàëèçèðîâàëè ðåçóëüòàòû 14 èññëåäîâàíèé (1546 áîëüíûõ), îïðåäåëèëè, ÷òî àäúþâàíòíàÿ ÕÒ ñïîñîáñòâóåò ïîâûøåíèþ ïîêà- çàòåëåé 2- è 5-ëåòíåé âûæèâàåìîñòè (ð = 0,044 è 0,0002 ñîîòâåòñòâåííî). Åùå áîëüøåå çíà÷åíèå èìååò àíàëèç äàííûõ îáñëåäîâàíèÿ êàæäîãî ïàöèåíòà èç óïîìÿíóòûõ 14 ðàíäîìèçèðîâàííûõ èññëåäîâàíèé [82]. Ìåäèàíà ñðîêà íàáëþäåíèÿ ñîñòàâèëà 9,4 ãîäà. Îêàçàëîñü, ÷òî ïðèìåíåíèå àäúþâàíòíîé ÕÒ íà îñíîâå äîêñîðóáèöèíà óâåëè÷èëî âðåìÿ äî ïîÿâ- Òàáëèöà 6 Ðàíäîìèçèðîâàííûå èññëåäîâàíèÿ ýôôåêòèâíîñòè ÕÒ ïðè ðàñïðîñòðàíåííûõ ôîðìàõ ÑÌÒ Èññëåäîâàòåëü- ñêàÿ ãðóïïà Ðåæèì ÕÒ Êîëè÷åñòâî áîëüíûõ Ýôôåêòèâ- íîñòü (%) Óëó÷øàþòñÿ ëè ïîêàçàòåëè ýôôåêòèâíîñòè ëå÷åíèÿ? Óëó÷øàþòñÿ ëè ïîêàçàòåëè îáùåé âûæèâàåìîñòè? ECOG [83] Äîêñîðóáèöèí 200 27 - - Äîêñîðóáèöèí/âèíêðèñòèí 19 Håò Håò Öèêëîôîñôàìèä/àêòèíîìèöèí D/âèíêðèñòèí 11 Håò Håò ECOG [17] Äîêñîðóáèöèí (70 ìã/ì 2 ) 275 18 - - Äîêñîðóáèöèí (45 ìã/ì 2 ) 16 Håò Håò Äîêñîðóáèöèí/äàêàðáàçèí 30 Äà Håò ECOG [18] Äîêñîðóáèöèí 298 17 - - Äîêñîðóáèöèí/âèíäåñèí 18 Håò Håò ECOG [36] Äîêñîðóáèöèí 262 20 - - Äîêñîðóáèöèí/èôîñôàìèä 34 Äà Håò Äîêñîðóáèöèí/ìèòîìèöèí Ñ/öèñïëàòèí 32 Äà Håò SWOG [9] Äîêñîðóáèöèí/äàêàðáàçèí 276 33 - - Äîêñîðóáèöèí/öèêëîôîñôàìèä/äàêàðáàçèí 34 Håò Håò Äîêñîðóáèöèí/àêòèíîìèöèí D/äàêàðáàçèí 24 Håò Håò EORTC [81] Äîêñîðóáèöèí 663 23 - - Äîêñîðóáèöèí/èôîñôàìèä 28 Håò Håò Äîêñîðóáèöèí/âèíêðèñòèí/öèêëîôîñôàìèä/ àêòèíîìèöèí D 28 Håò Håò ISSG [5] Äîêñîðóáèöèí/äàêàðáàçèí 340 17 - - Äîêñîðóáèöèí/èôîñôàìèä/äàêàðáàçèí/ìåñíà 32 Äà Håò Òàáëèöà 7 Ðàíäîìèçèðîâàííûå èññëåäîâàíèÿ àäúþâàíòíîé ÕÒ ÑÌÒ Èñòî÷- Ðåæèì ÕÒ Êîëè÷åñòâî % áåçðåöèäèâíîé âûæèâàåìîñòè % îáùåé âûæèâàåìîñòè íèê áîëüíûõ áåç àäúþ- âàíòíîé ÕÒ ïîñëå àäúþ- âàíòíîé ÕÒ p áåç àäúþ- âàíòíîé ÕÒ ïîñëå àäúþ- âàíòíîé ÕÒ p [20] Äîêñîðóáèöèí/öèêëîôîñôàìèä/âèíêðèñòèí/äàêàðáàçèí 468 43 56 0,007 56 63 NS [78] Äîêñîðóáèöèí/öèêëîôîñôàìèä/âèíêðèñòèí/äàêàðáàçèí 59 16 57 p < 0,01 53 87 p < 0,01 [35] Äîêñîðóáèöèí/âèíêðèñòèí/äàêàðáàçèí/àêòèíîìèöèí D 61 68 65 NS 70 70 NS [13] Äîêñîðóáèöèí/öèêëîôîñôàìèä/âèíêðèñòèí/àêòèíîìèöèí D 43 35 54 < 0,05 46 65 NS [80] Äîêñîðóáèöèí/öèêëîôîñôàìèä/ìåòîòðåêñàò 31 49 77 0,075 58 68 NS [47] Äîêñîðóáèöèí/öèêëîôîñôàìèä/ìåòîòðåêñàò 22 47 92 0,01 61 82 NS [48] Äîêñîðóáèöèí/öèêëîôîñôàìèä/ìåòîòðåêñàò 15 - - - 100 47 0,06 [29] Äîêñîðóáèöèí/öèêëîôîñôàìèä/ìåòîòðåêñàò 67 28 54 < 0,05 60 54 NS [43] Ýïèðóáèöèí/èôîñôàìèä 104 37 51 0,008 54 67 0,002 [2] Äîêñîðóáèöèí 181 56 62 NS 65 68 NS [6] Äîêñîðóáèöèí 181 56 62 NS 65 68 NS [71] Äîêñîðóáèöèí 156 47 59 NS 52 60 NS [37] Äîêñîðóáèöèí 119 54 56 NS 74 78 NS [45] Äîêñîðóáèöèí 77 45 73 < 0,05 70 91 < 0,05 [59] Äîêñîðóáèöèí 47 - - NS - - NS NS � ðàçëè÷èÿ íåäîñòîâåðíû. ÎÍÊÎËÎÃÈß � Ò. 2 � ¹ 1�2 � 2000 129 Ê Î Ð Ï Î Ð À Ò È Â Í À ß È Í Ô Î Ð Ì À Ö È ß ëåíèÿ îòäàëåííûõ ìåòàñòàçîâ íà 10% (ñ 60 äî 70%, ð = 0,0003), ìåñòíûõ ðåöèäèâîâ � íà 6% (ñ 75 äî 81%, ð = 0,024), äëèòåëüíîñòü áåçðåöèäèâíîãî ïåðèîäà � íà 13% (ñ 45 äî 58%, ð = 0,000008), à áåçðåöèäèâíóþ âûæèâàåìîñòü � íà 11% (ñ 40 äî 51%, ð = 0,00008), ÷òî, ïî ìíåíèþ àâòîðîâ, ÿâëÿ- åòñÿ îñíîâîé äëÿ ïîâûøåíèÿ îáùåé âûæèâàåìî- ñòè. Ýòîò ïîêàçàòåëü óëó÷øèëñÿ íà 5% [82]. Íà îñíîâàíèè ðåçóëüòàòîâ ðàíäîìèçèðîâàííûõ èññëåäîâàíèé è ìåòààíàëèçà, âåäóùèå êëèíèöèñòû ïîëàãàþò, ÷òî àäúþâàíòíàÿ ÕÒ ïîêà íå ìîæåò ñ÷è- òàòüñÿ ñòàíäàðòíûì ìåòîäîì ëå÷åíèÿ ïðè ëîêàëü- íûõ ôîðìàõ ÑÌÒ. Ýòîò ìåòîä ëå÷åíèÿ ìîæíî ïðè- ìåíÿòü â äàëüíåéøåì òîëüêî ó áîëüíûõ ñ íåáëàãî- ïðèÿòíûìè ïðîãíîñòè÷åñêèìè ôàêòîðàìè (îïóõîëü áîëüøå 5 ñì, âûñîêàÿ ñòåïåíü èíâàçèè) [76]. Håîàäúþâàíòíàÿ ÕÒ. Ïðåäîïåðàöèîííàÿ ÕÒ ñïîñîáíà óëó÷øèòü ðåçóëüòàòû ëå÷åíèÿ ÑÌÒ ïó- òåì ñíèæåíèÿ ðèñêà ïðîãðåññèðîâàíèÿ îïóõîëè è ýëèìèíàöèè ñóáêëèíè÷åñêèõ ìåòàñòàçîâ. Êðîìå òîãî, íåîàäúþâàíòíàÿ ÕÒ ìîæåò îêàçûâàòü àääè- òèâíîå èëè ñèíåðãè÷åñêîå äåéñòâèå ïðè ïðîâåäå- íèè ïåðåäîïåðàöèîííîé ëó÷åâîé òåðàïèè è òàêèì îáðàçîì ïðåâðàùàòü íåîïåðàáåëüíûå îïóõîëè â îïåðàáåëüíûå [27]. Håîàäúþâàíòíàÿ ÕÒ ÿâëÿåòñÿ ñòàíäàðòíûì ìåòîäîì ëå÷åíèÿ äåòåé ñ ðàáäîìèî- ñàðêîìîé, îñòåîñàðêîìîé è ñàðêîìîé Þèíãà. Ó âçðîñëûõ ýòîò ïîäõîä ïîêà òîëüêî èññëåäóþò. Håñêîëüêî èññëåäîâàíèé â ýòîì íàïðàâëåíèè ïðîâîäèëîñü â ÑØÀ íà÷èíàÿ ñ 1974 ã. Íåäàâíî ñîîáùàëîñü î ðåçóëüòàòàõ äâóõ èññëåäîâàíèé, ñî- ãëàñíî êîòîðûì ýôôåêòèâíîñòü íåîàäúþâàíòíîé ÕÒ ñîñòàâèëà 24�27% [75, 77]. ×àñòîòà ïîñëåîïå- ðàöèîííûõ îñëîæíåíèé íå çàâèñåëà îò ïðîâåäåíèÿ íåîàäúþâàíòíîé ÕÒ [65]. Èçâåñòíû ðåçóëüòàòû åäèíñòâåííîãî ïîêà èññëåäîâàíèÿ, â êîòîðîì ñ òà- êîé öåëüþ ïðèìåíÿëè èôîñôàìèä â êîìáèíàöèè ñ äîêñîðóáèöèíîì (à òàêæå öèñïëàòèíîì). Ýôôåê- òèâíîñòü ëå÷åíèÿ ñîñòàâèëà 43% [93]. Ñîãëàñíî íåäàâíî îïóáëèêîâàííûì äàííûì ñêàíäèíàâñêèõ îíêîëîãîâ, íåîàäúþâàíòíàÿ ÕÒ óëó÷øàåò ðåçóëü- òàòû âûæèâàåìîñòè áîëüíûõ ÑÌÒ [40]. Èíòåðåñíûì íàïðàâëåíèåì â ëå÷åíèè ÑÌÒ ÿâëÿåòñÿ óäàëåíèå ìåòàñòàçîâ â ëåãêèõ [1]. Ñîãëàñ- íî ïðåäñòàâëåííûì íà êîíôåðåíöèè ASCO â 1999 ã. ñâîäíûì äàííûì EORTC, ó áîëüíûõ ñ ìå- òàñòàçàìè òîëüêî â ëåãêèõ ýôôåêòèâíîñòü ëå÷å- íèÿ âûøå, ÷åì ó ïàöèåíòîâ ñ ìåòàñòàçàìè äðóãîé ëîêàëèçàöèè, � 31 ïðîòèâ 23% [46]. Ïðåäïîëàãà- åòñÿ, ÷òî ÕÒ (â ÷àñòíîñòè, íåîàäúþâàíòíàÿ) ìî- æåò óëó÷øàòü ðåçóëüòàòû ëå÷åíèÿ áîëüíûõ ñ ìå- òàñòàçàìè â ëåãêèõ. Ýòîé ïðîáëåìå ïîñâÿùåíû äâà ïðîâîäÿùèõñÿ â íàñòîÿùåå âðåìÿ ðàíäîìèçèðî- âàííûõ èññëåäîâàíèÿ EORTC [52]. Îñîáåííîñòè ëå÷åíèÿ áîëüíûõ ñ îòäåëüíûìè òèïàìè ÑÌÒ. Êàê óæå îòìå÷àëîñü, ðàçëè÷àþò ÑÌÒ íåñêîëüêèõ äåñÿòêîâ ïîäòèïîâ â çàâèñèìî- ñòè îò ãèñòîëîãè÷åñêîé ñòðóêòóðû è ëîêàëèçàöèè.  ðàíäîìèçèðîâàííûõ èññëåäîâàíèÿõ ýòè ïîäòè- ïû ÷àùå âñåãî àíàëèçèðóþò âìåñòå. Îäíàêî ìíî- ãèå àâòîðû îòìå÷àþò îñîáåííîñòè ëå÷åíèÿ ïðè ðàçëè÷íûõ òèïàõ ÑÌÒ. Òàê, íàèìåíåå ÷óâñòâè- òåëüíîé ê ÕÒ ñðåäè ÑÌÒ ÿâëÿåòñÿ, î÷åâèäíî, ëåéîìèîñàðêîìà ïèùåâàðèòåëüíîãî òðàêòà. Äðóãîé ôîðìîé ÑÌÒ, ðåçèñòåíòíîé ê ÕÒ, ñ÷èòàþò íåé- ðîôèáðîñàðêîìó. Åñòü äàííûå, ÷òî ñèíîâèàëüíàÿ ñàðêîìà ìîæåò áûòü îòíîñèòåëüíî áîëåå ÷óâñòâè- òåëüíîé ê èôîñôàìèäó â âûñîêèõ äîçàõ.  äâóõ ðàçëè÷íûõ èññëåäîâàíèÿõ ýôôåêòèâíîñòü òàêîãî ëå÷åíèÿ ñîñòàâèëà ïî÷òè 100% [36, 53]. Èçâåñòíî, ÷òî ðåçóëüòàòû ëå÷åíèÿ äåòåé ñ ÑÌÒ ñóùåñòâåííî ëó÷øå. Àëüâåîëÿðíûå è ýìáðèîíàëüíûå ðàáäîìèîñàðêîìû ÿâëÿþòñÿ íàèáîëåå ÷àñòî âûÿâëÿå- ìûìè ôîðìàìè ÑÌÒ ó äåòåé. Äî íà÷àëà àêòèâíîãî ïðèìåíåíèÿ ÕÒ îêîëî 80% áîëüíûõ ñ ðàáäîìèîñàð- êîìîé ïîãèáàëè, íåñìîòðÿ íà àãðåññèâíîå ìåñòíîå ëå÷åíèå (îïåðàöèÿ + îáëó÷åíèå).  íàñòîÿùåå âðåìÿ îêîëî 70% òàêèõ ïàöèåíòîâ, â òîì ÷èñëå 20�30% ñ ìåòàñòàòè÷åñêèì ïðîöåññîì ïîëíîñòüþ èçëå÷èâàþò- ñÿ. Ëå÷åíèå âçðîñëûõ ñ ðàáäîìèîñàðêîìîé îñíîâàíî íà òåõ æå ïðèíöèïàõ, êîòîðûå ñ óñïåõîì ïðèìåíÿ- þòñÿ ïðè ëå÷åíèè äåòåé.  ÷àñòíîñòè, ðåêîìåíäóþò ðåæèìû, ðàçðàáîòàííûå Intergroup Rhabdomyo- sarcoma Study (IRS-III èëè IRS-IV) [86]. Ðîëü ÕÒ ïðè ÑÌÒ ïðîäîëæàþò àêòèâíî èçó- ÷àòü. Hàïðèìåð, íà 1 àïðåëÿ 2000 ã. â áàçå äàííûõ Hàöèîíàëüíîãî èíñòèòóòà ðàêà ÑØÀ èìåëàñü èíôîðìàöèÿ î 4 ðàíäîìèçèðîâàííûõ èññëåäîâà- íèÿõ ïðè ÑÌÒ ó âçðîñëûõ [52]: EORTC-62931 Àäúþâàíòíàÿ âûñîêîäîçîâàÿ ÕÒ (äîêñîðóáèöèí/èôîñôàìèä) ïðè ÑÌÒ âûñî- êîé ñòåïåíè çëîêà÷åñòâåííîñòè EORTC-62933 Håîàäúþâàíòíàÿ âûñîêîäîçî- âàÿ ÕÒ (äîêñîðóáèöèí/èôîñôàìèä ± G-CSF) è óäàëåíèå ìåòàñòàçîâ â ëåãêèõ ïî ñðàâíåíèþ ñ òîëü- êî óäàëåíèåì ìåòàñòàçîâ ÑÌÒ EORTC-62971 Äâå ðàçëè÷íûå äîçû èôîñôà- ìèäà ïðîòèâ äîêñîðóáèöèíà ïðè ðàñïðîñòðàíåí- íûõ ôîðìàõ ÑÌÒ EORTC-62961 Håîàäúþâàíòíàÿ ÕÒ (ýòîïî- çèä/èôîñôàìèä/äîêñîðóáèöèí) â êîìáèíàöèè ñ ìåñòíîé ãèïåðòåðìèåé ïî ñðàâíåíèþ ñ òîëüêî íåîàäúþâàíòíîé ÕÒ ïðè ÑÌÒ âûñîêîé ñòåïåíè çëîêà÷åñòâåííîñòè. Òàêèì îáðàçîì, íàèáîëåå ýôôåêòèâíûìè öè- òîñòàòèêàìè ÿâëÿþòñÿ äîêñîðóáèöèí è èôîñôà- ìèä, ïðè÷åì óñòàíîâëåíà çàâèñèìîñòü ýôôåêòèâ- íîñòè îáîèõ ïðåïàðàòîâ îò äîçû. 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Chemotherapy could be used both for radical and for palliative treatment. For rhabdomyosarcoma, chemotherapy is effective in all the stages of such disease. Key Words: chemotherapy, soft tissue sarcoma, adults.
id nasplib_isofts_kiev_ua-123456789-32929
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
issn 1562-1774,0204-3564
language Russian
last_indexed 2025-12-07T17:56:14Z
publishDate 2000
publisher Iнститут експериментальної патології, онкології і радіобіології ім. Р. Є. Кавецького
record_format dspace
spelling Шпарик, Я.В.
2012-05-26T10:55:40Z
2012-05-26T10:55:40Z
2000
Химиотерапия взрослых больных с саркомами мягких тканей / Я.В. Шпарик // Онкологія. — 2000. — Т. 2, № 1. — С. 126-132. — Бібліогр.: 96 назв. — рос.
1562-1774,0204-3564
https://nasplib.isofts.kiev.ua/handle/123456789/32929
В обзоре рассмотрены общие принципы цитостатического лечения взрослых больных с саркомами мягких тканей. Роль химиотерапии при этом заболевании на протяжении последних лет повышается. Hаиболее эффективными цитостатиками являются доксорубицин и ифосфамид, причем у обоих препаратов установлена зависимость эффективности от дозы. Химиотерапию применяют как элемент радикального комбинированного лечения, а также как паллиативный метод при метастатическом процессе. При рабдомиосаркоме химиотерапия эффективна практически при любой стадии заболевания.
Chemotherapy has an increasing role in the therapy of soft tissue sarcomas. Meanwhile, chemotherapy of these tumors is frequently considered in general without taking into account the peculiar clinical features of various subtypes. Doxorubicin and ifosfamide are the most active drugs in the treatment of soft tissue sarcomas. Chemotherapy could be used both for radical and for palliative treatment. For rhabdomyosarcoma, chemotherapy is effective in all the stages of such disease.
ru
Iнститут експериментальної патології, онкології і радіобіології ім. Р. Є. Кавецького
Онкологія
Корпоративная информация
Химиотерапия взрослых больных с саркомами мягких тканей
Chemotherapy of soft tissue sarcomas in adult
Article
published earlier
spellingShingle Химиотерапия взрослых больных с саркомами мягких тканей
Шпарик, Я.В.
Корпоративная информация
title Химиотерапия взрослых больных с саркомами мягких тканей
title_alt Chemotherapy of soft tissue sarcomas in adult
title_full Химиотерапия взрослых больных с саркомами мягких тканей
title_fullStr Химиотерапия взрослых больных с саркомами мягких тканей
title_full_unstemmed Химиотерапия взрослых больных с саркомами мягких тканей
title_short Химиотерапия взрослых больных с саркомами мягких тканей
title_sort химиотерапия взрослых больных с саркомами мягких тканей
topic Корпоративная информация
topic_facet Корпоративная информация
url https://nasplib.isofts.kiev.ua/handle/123456789/32929
work_keys_str_mv AT šparikâv himioterapiâvzroslyhbolʹnyhssarkomamimâgkihtkanei
AT šparikâv chemotherapyofsofttissuesarcomasinadult