Дiя адрiамiцину на бiоенергетичнi процеси в тканинах печiнки та серця щурiв i ї ї корекцiя попередниками та модуляторами бiосинтезу убiхiнону
The results of studies of the effect of complexes of precursors and modulators of coenzyme Q biosynthesis bioenergetical processes under adriamycin-induced cardiomyopathy are given. We show that adriamycin-induced cardiomyopathy is characterized by changes in bioenergetical processes, particularly...
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| Date: | 2007 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | Ukrainian |
| Published: |
Видавничий дім "Академперіодика" НАН України
2007
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| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/3836 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Дiя адрiамiцину на бiоенергетичнi процеси в тканинах печiнки та серця щурiв i ї ї корекцiя попередниками та модуляторами бiосинтезу убiхiнону / О.Б. Кучменко, Д.М Петухов, Г.В. Донченко // Доп. НАН України. — 2007. — № 12. — С. 167-172. — Бібліогр.: 14 назв. — укp. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | The results of studies of the effect of complexes of precursors and modulators of coenzyme Q biosynthesis bioenergetical processes under adriamycin-induced cardiomyopathy are given. We show that adriamycin-induced cardiomyopathy is characterized by changes in bioenergetical
processes, particularly in the coenzyme Q content and in the activity of complexes II and IV of the mitochondrial electron transport chain. Treatment of experimental animals with complexes of precursors and modulators of coenzyme Q biosynthesis normalizes the coenzyme Q content
and the function of the mentioned enzyme complexes. Data presented may become a basement for the development of approaches to adriamycin cardiotoxicity correction.
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| ISSN: | 1025-6415 |