Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats
It is shown, that week drinking of bioactive water Naftussya spa Truskavets' causes both vagotonic effectes (less often) as well as sympathotonic effectes (more often) on basal vegetative regulation in rats. It is detected four predictors which enables forecasting of vagotonic effect with accur...
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Інститут фізіології ім. О.О. Богомольця НАН України
2008
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| Cite this: | Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats / O.V. Kozyavkina, L.G. Barylyak // Медична гідрологія та реабілітація. — 2008. — Т. 6, № 3. — С. 123-127. — Бібліогр.: 24 назв. — англ. |
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| author | Kozyavkina, O.V. Barylyak, L.G. |
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| citation_txt | Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats / O.V. Kozyavkina, L.G. Barylyak // Медична гідрологія та реабілітація. — 2008. — Т. 6, № 3. — С. 123-127. — Бібліогр.: 24 назв. — англ. |
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| description | It is shown, that week drinking of bioactive water Naftussya spa Truskavets' causes both vagotonic effectes (less often) as well as sympathotonic effectes (more often) on basal vegetative regulation in rats. It is detected four predictors which enables forecasting of vagotonic effect with accuracy of 89 %, sympathotonic effect - 46 %; total correctly of prognosis - 77 %.
В експерименті на 58 щурах лінії Wistar обох статей виявлено амбівалентні впливи тижневого вживання біоактивної води Нафтуся на показники вегетативної регуляції, оцінені методом варіаційної кардіоінтервалометрїї. Методами дискримінантного і канонікального аналізів показана можливість прогнозування симпато- і ваготонічного ефектів за низкою початкових показників-предикторів: аеробною м'язевою працездатністю, статтю, резистентністю до гострої гіпоксії та масою тіла.
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123
UDC 616.003. 96-616.45-001.1/3-616-084
O.V. KOZYAVKINA, L.G. BARYLYAK
AMBIVALENT VEGETOTROPIC EFFECTS OF BIOACTIVE WATER NAFTUSSYA AND
OPPORTUNITY OF THEIR FORECASTING AT RATS
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INTRODUCTION
The results both clinical-physiological, and experimental researches of immediate and course effects
of bioactive water Naftussya (BAWN) of spa Truskavets' on vegetative nervous system are ambiguous:
there are found out both vagotonic, and sympathotonic effects, and also uncertain [3,7,8-12,15,16,21].
Therefore the problem remains actual, which that has defined a theme of our research.
TECHNIQUE
The chronic experiment on 58 male and female rats of a line Wistar with weight of a body 200-250 is
carried out. At a preparatory stage all animals were tested on resistance to hypoxia (estimated on time of
second agonal breath after creation in barochamber of pressure air 145 mm Hg) [1,5] and aerobic
muscular serviceability (estimated on duration of swimming in warm water with aggravation up to a
complete exhaustion) [1,6]. One week after there were defined parameters of vegetative regulation by a
method of variational cardiointervalometry of electrocardiogramma (ECG) [2], registered under easy
aether narcose after introduction under skin the needle electrodes. At the following stage of experiment 10
rats remained intact, and the others loaded through metallic tube by BAWN (chink 21N of Truskavetsian
deposit) in a doze of 20 ml/kg unitary within 7 days. The next day after ending a drinking course they first
repeatedly registered ECG, and then subjected rats to acute stress by a premise them in close crates and
immersings last up to a level of processus xyphoideus in cold (t
o
20-21
o
C) water for 4 hours [17,23]. Some
days after water immersion reastraint stress they took away test of blood from cuted tip of a tail (for
biochemical and immunologic tests) and once again they registered ECG.
The results are processed on $� under the program Statistica with the use of methods of the
variational, discriminant and canonical analyses [20].
RESULTS AND THEIR DISCUSSION
Retrospectively the two types of effects of BAWN on basal vegetative regulation (Table 1) are
revealed. At 73 % rats the amplitude of moda (% �) as a correlate of sympathotone was considerably
reduced, whereas a variational swing (D4) as a correlate of vagotone in the greater degree raised at
absence of significantly changes of size of moda ( �), which reflecs humoral channal of regulation. In
aggregate it testifies about vagotonic character of vegetotropic effect. At 27 % rats, on the contrary, are
ascertained sympathotonic changes of parameters vegetative regulation: significant increase of
sympathotone in combination with less expressed decrease of vagotone and sympathotonic shift of
humoral channal of regulation.
Thus, week drinking of BAWN causes both vagotonic effectes (more often) as well as
sympathotonic effectes (less often) on basal vegetative regulation in rats.
It is necessary to believe, that sympathotonic effect of BAWN is caused by contained in its structure
organic substances [1], among which, probably, are available inhibitors of catechol-o-methyltransferase,
as it is established for phytoadaptogens [4,13]. Vagotonic effect of BAWN has, probably, reflectory
mechanism.
124
With the purpose of finding-out a probable conditionizing role of initial parameters in various
directed vegetotropic effects of BAWN the procedure of discriminant analysis (method forward stepwise)
is carried out. It turned out ((able 2), that all four registered parameters are predictive factors
conditionizing the character of vegetotropic effect of BAWN.
Table 1. The ambivalent effects of week using of BAWN on basal vegetative regulation in rats
Type of vegetotropic effect by using of BAWN
Vagotonic (n=35) Sympathotonic (n=13)
Parameters of
vegetative
regulation
Vegetative
regulation in
control (intact)
(n=10) Basal After stress Basal After stress
Sympathotone
(AMo), %
X±m
ID±m
d±m
43±5
1,00±0,12
0,00±0,31
30±2c
0,70±0,04c
-0,81±0,12c
58±3c
1,34±0,08c
+0,92±0,22c
77±3cv
1,77±0,08cv
+2,08±+0,22cv
80±4cv
1,84±0,10cv
+2,27±0,26cv
Vagotone
(DX), ms
X±m
ID±m
d±m
59±16
1,00±0,27
0,00±0,31
109±11c
1,85±0,20c
+0,98±0,23c
35±5
0,60±0,08c
-0,46±0,09c
21±3cv
0,37±0,05cv
-0,73±0,06cv
14±2cv
0,23±0,03cv
-0,89±0,03cv
Humoral channal of
regulation (Mo), ms
X±m
ID±m
d±m
203±23
1,00±0,11
0,00±0,31
197±6
0,97±0,03
-0,09±0,08
170±5
0,84±0,03c
-0,45±0,07c
146±3cv
0,72±0,01cv
-0,79±0,04
147±7cv
0,73±0,04cv
-0,76±0,10cv
Comments: 1. X±m - mean and its standart error.
2. ID±m - index of deviation from control and its standart error.
3. d±m - Euklidian distance from control and its standart error.
4. Significantly differences benween control (C) and both types; benween vagotonic (V) and
sympathotonic effects.
Table 2. The predictive factors conditionizing character of vegetotropic effect of BAWN in rats
Vegetotropic effect of BAWN
Predictive
factors
Group
Param-s
Control
(n=10)
Vagotonic
(n=35)
Sympathotoni
c (n=13)
Parameters
of Wilks' statistics
Swimming test,
min
X±m
ID±m
d±m
CCF
19,2±5,9
1,00±0,30
0,00±0,31
16,2±1,4
0,84±0,07�
-0,16±0,07�
-0,006
24,5±4,2
1,33±0,22v
+0,34±0,23v
0,086
E
F
p
0,863
7,29
0,010
CVCR
SCCV
RCCV
-0,654
-0,723
-0,068
Sex-index
(male=1,
female=2)
X±m
ID±m
d±m
CCF
1,50±0,17
1,00±0,11
0,00±0,31
1,63±0,08
1,09±0,05
+0,24±0,16
14,24
1,23±0,12v
0,82±0,08v
-0,51±0,23v
12,35
E
F
p
0,801
5,56
0,007
CVCR
SCCV
RCCV
0,622
0,673
1,411
Weight of body,
g
X±m
ID±m
d±m
CCF
206±7
1,00±0,03
0,00±0,31
223±5�
1,08±0,03�
+0,78±0,23�
0,316
224±8
1,09±0,04c
+0,80±0,37c
0,294
E
F
p
0,769
4,40
0,009
CVCR
SCCV
RCCV
-0,010
0,516
0,017
Hypoxic test,
sec
X±m
ID±m
d±m
CCF
134±26
1,00±0,19
0,00±0,31
125±10
0,93±0,08
-0,11±0,13
0,004
147±20
1,10±0,15
+0,16±0,25
0,013
E
F
p
0,730
3,98
0,008
CVCR
SCCV
RCCV
-0,255
-0,447
-0,007
�onst. -47,45 -43,84 �onst. -3,741
Comments: 1. CCF - coefficients of classification functions and constants.
2. CVCR - correlations variables-canonical root.
3. SCCV - standardized coefficients for canonical variables.
4. RCCV - raw coefficients for canonical variables.
Thus BAWN renders vagotonic effect on rats, as a rule, female with smaller, in comparison with the
average control, aerobic muscular capacity and resistance to hypoxia. On the contrary, excess of average
levels of swimming and hypoxic testes and belonging to a male conditionizes in aggregate sympathotonic
effect of BAWN. The weight of body is also included in model, which is a little bit increased owing to a
week course of drinking.
125
Discriminant information is condensed in unique canonical variable (root). Pooled-within-groups
correlations (CVCR) are essential concerning swimming test and sex-index, but not concerning hypoxic
test and weight of body ((able 2).
Means of canonical variabl�s (Fig. 1) at rats with vagotonic and sympathotonic reactions make
+0,36±0,17 versus -0,98±0,29 respectively, that is unstandardized canonical scores in the first case, as a
rule, are positive, and in the second case they are almost exclusively negative. Squared Mahalanobis
distance between groups makes 1,88 (F=3,89; p=0,009). Summary tests with successive root removed:
canonical r
*
=0,52; Wilks' E=0,73; P2
=13,9; p=0,008. The calculation of classification functions by
addition of products of individual sizes of predictive factors on coefficients of classification functions plus
constant enables forecasting of vagotonic effect with accuracy of 89 %, sympathotonic effect - 46 %; total
correctly of prognosis - 77 %.
If discriminant analysis allows forecasting only the character vegetotropic effect of BAWN, then
with the help of canonical analysis it is possible with the certain degree of probability to anticipate
quantitative changes parameters of vegetative regulation. It is revealed (Table 3), that if separate
predictors correlates with separate parameters of vegetative regulation weakly or moderately, the
constellations are connected already considerably: canonical r
*
=0,54; P2
=25,0; E Prime=0,56; p=0,015.
Thus the first root of predictive factors is correlates with swimming test very close (r=0,84), with
sex-index correlates weaker (r=-0,71), both with weight of body (r=0,37) and hypoxic test (r=0,25)
correlates moderately. On the other hand, the information contents in first root of vegetative parameters is
determined in the maximal degree by sympathotone (r=0,985), to a lesser degree by vagotone (r=-0,75)
and humoral channal (r=-0,76).
Fig. 1. Unstandardized canonical scores in rats with vagotonic (V) and sympathotonic
(S) balneoreactions on drinking of BAWN
-3
-2,5
-2
-1,5
-1
-0,5
0
0,5
1
1,5
2
V V V V V V V V V V V V V V V V V V V V V V V V V V V V V V V V V V V S S S S S S S S S S S S S
Root
126
Table 3. Matrix of between and within correlations
Parameters Code 1 2 3 4 5 6 7
Sex-index 1 1 -0,32 -0,01 -0,33 0,46 -0,33 0,33
Swimming test 2 1 -0,05 0,30 -0,30 0,45 -0,32
Hypoxic test 3 1 0,13 0,08 0,18 -0,07
Weight of body 4 1 -0,09 0,21 -0,19
Humoral channal 5 1 -0,64 0,74
Sympathotone 6 1 -0,70
Vagotone 7 1
Second root of predictive factors is determined considerably by hypoxic test (r=-0,66) and sex-index
(r=-0,56), but it is weak determined by weight of body (r=-0,28) and swimming test (r=-0,14). Parameters
of vegetative regulation correlates with second root in such sequence: Mo (r=-0,62), AMo (r=-0,17), DX
(r=-0,09). Tests with successive root removed: canonical r
*
=0,45; P2
=10,4; E Prime=0,78; p=0,108.
Third pair does not deserve attention because of the statistics: canonical r
*
=0,10; P2
=0,47; E
Prime=0,99; p=0,79.
Canonical connections between roots of predictive factors (right set) and vegetative parameters (left
set) are represented on Fig. 2.
Fig. 2. Canonical correlation between predictive factors (axis 4) and parameters of vegetative
regulation after drinking BAWN (axis Y)
Root 1 Root 2
The equations of first and second of pairs roots:
0,851GAmo - 0,237GMo + 0,026GJX = -0,502GSex + 0,702GSwim - 0,047GWeight + 0,294GHypox
-1,454GMo - 0,806GAmo + 0,425GJX = -0,627GHypox - 0,780GSex - 0,365GWeight - 0,311GSwim
Revealed by us close inverse correlation between sympathotone and vagotone is very known
[14,18,19,22].
Acute stress at rats with vagotonia induced by BAWN is accompanied by less expressed rise of
sympathotone and fall of vagotone, and also the size of � in comparison with the postsressory changes at
rats with sympathotonia.
As stress renders distinct influence on immune system [24], it is interesting to look after
accompanying immunotropic effects, that will be a theme of following our message.
Right set
L
e
ft
s
e
t
-2
-1
0
1
2
3
4
-2.5 -1.5 -0.5 0.5 1.5 2.5
Right set
L
e
ft
s
e
t
-2.5
-1.5
-0.5
0.5
1.5
2.5
-5.0 -3.5 -2.0 -0.5 1.0 2.5
127
O.V. KOZYAVKINA, L.G. BARYLYAK
AMBIVALENT VEGETOTROPIC EFFECTS OF BIOACTIVE WATER NAFTUSSYA AND
OPPORTUNITY OF THEIR FORECASTING AT RATS
It is shown, that week drinking of bioactive water Naftussya spa Truskavets' causes both vagotonic
effectes (less often) as well as sympathotonic effectes (more often) on basal vegetative regulation in rats.
It is detected four predictors which enables forecasting of vagotonic effect with accuracy of 89 %,
sympathotonic effect - 46 %; total correctly of prognosis - 77 %.
LITERATURE
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|
| id | nasplib_isofts_kiev_ua-123456789-41685 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | XXXX-0046 |
| language | English |
| last_indexed | 2025-11-30T13:54:48Z |
| publishDate | 2008 |
| publisher | Інститут фізіології ім. О.О. Богомольця НАН України |
| record_format | dspace |
| spelling | Kozyavkina, O.V. Barylyak, L.G. 2013-03-01T14:21:10Z 2013-03-01T14:21:10Z 2008 Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats / O.V. Kozyavkina, L.G. Barylyak // Медична гідрологія та реабілітація. — 2008. — Т. 6, № 3. — С. 123-127. — Бібліогр.: 24 назв. — англ. XXXX-0046 https://nasplib.isofts.kiev.ua/handle/123456789/41685 616.003. 96-616.45-001.1/3-616-084 It is shown, that week drinking of bioactive water Naftussya spa Truskavets' causes both vagotonic effectes (less often) as well as sympathotonic effectes (more often) on basal vegetative regulation in rats. It is detected four predictors which enables forecasting of vagotonic effect with accuracy of 89 %, sympathotonic effect - 46 %; total correctly of prognosis - 77 %. В експерименті на 58 щурах лінії Wistar обох статей виявлено амбівалентні впливи тижневого вживання біоактивної води Нафтуся на показники вегетативної регуляції, оцінені методом варіаційної кардіоінтервалометрїї. Методами дискримінантного і канонікального аналізів показана можливість прогнозування симпато- і ваготонічного ефектів за низкою початкових показників-предикторів: аеробною м'язевою працездатністю, статтю, резистентністю до гострої гіпоксії та масою тіла. en Інститут фізіології ім. О.О. Богомольця НАН України Медична гідрологія та реабілітація Експериментальна бальнеофізіологія Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats Article published earlier |
| spellingShingle | Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats Kozyavkina, O.V. Barylyak, L.G. Експериментальна бальнеофізіологія |
| title | Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats |
| title_full | Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats |
| title_fullStr | Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats |
| title_full_unstemmed | Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats |
| title_short | Ambivalent vegetotropic effects of bioactive water Naftussya and opportunity of their forecasting at rats |
| title_sort | ambivalent vegetotropic effects of bioactive water naftussya and opportunity of their forecasting at rats |
| topic | Експериментальна бальнеофізіологія |
| topic_facet | Експериментальна бальнеофізіологія |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/41685 |
| work_keys_str_mv | AT kozyavkinaov ambivalentvegetotropiceffectsofbioactivewaternaftussyaandopportunityoftheirforecastingatrats AT barylyaklg ambivalentvegetotropiceffectsofbioactivewaternaftussyaandopportunityoftheirforecastingatrats |