Структурное состояние мембранных белков эритроцитов человека при взаимодействии с лигандами β1-адренорецепторов — добутамином и атенололом
Interaction of β1-adrenoreceptor ligands, dobutamine and atenolol, with human erythrocyte membranes by acrylamide quenching the intinsic protein fluorescence has been investigated. It is shown that, by binding with membranes, these ligands form protein conformations having different efficiencies and...
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| Date: | 2008 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | Russian |
| Published: |
Видавничий дім "Академперіодика" НАН України
2008
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| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/6238 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Структурное состояние мембранных белков эритроцитов человека при взаимодействии с лигандами β1-адренорецепторов — добутамином и атенололом / В.В. Жирнов, С.В. Хижняк, В.М. Войцицкий, Е.А. Лапоша // Доп. НАН України. — 2008. — № 11. — С. 176-181. — Бібліогр.: 15 назв. — рос. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | Interaction of β1-adrenoreceptor ligands, dobutamine and atenolol, with human erythrocyte membranes by acrylamide quenching the intinsic protein fluorescence has been investigated. It is shown that, by binding with membranes, these ligands form protein conformations having different efficiencies and availabilities for the quenching by acrylamide. The findings allow us to assume that atenolol is an inversion antagonist of human β1-adrenoreceptors, i. e. it is capable to inhibit the basal activity of these receptors shifting the equilibrium between active and nonactive conformations toward the last.
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| ISSN: | 1025-6415 |