In silico analysis of the structure of variable domains of mouse single-chain antibodies specific to the human recombinant interferon β1b

• Published in: Цитология и генетика
• Date: 2009
• Main Authors: Flyak, A.I., Pavlova, M.V., Gilchuk, P.V.
• Format: Article
• Language: English
• Published: Інститут клітинної біології та генетичної інженерії НАН України 2009
• Subjects: Оригинальные работы
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/66623
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: In silico analysis of the structure of variable domains of mouse single-chain antibodies specific to the human recombinant interferon β1b / A.I. Flyak, M.V. Pavlova, P.V. Gilchuk // Цитология и генетика. — 2009. — Т. 43, № 1. — С. 54-60. — Бібліогр.: 19 назв. — англ.

In silico analysis of the DNA encoding singlechain Fv antibodies (ScFv) specific to the human recombinant interferon β1b and α2b (rhIFNβ1b, rhIFNα2b) has been carried out. The V, D and J-gene segments, the complementaritydetermining (CDR) and framework (FR) regions, n-nucleotides as well as mutation...