Expression of genes belonging to the IGF-system in glial tumors
The discrepancies arising from conflicting evidence on the results obtained by different laboratories in human gliomas are discussed. Our data highlight the importance of viewing the IGF-related proteins as a complex multifactorial system and show that changes in the expression levels of any one com...
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| Date: | 2011 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут клітинної біології та генетичної інженерії НАН України
2011
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| Series: | Цитология и генетика |
| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/66864 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Expression of genes belonging to the IGF-system in glial tumors / V.V. Dmitrenko, V.M. Kavsan, O.I. Boyko, V.I. Rymar, A.A. Stepanenko, O.V. Balynska, T.A. Malisheva, V.D. Rozumenko, Y.P. Zozulya // Цитология и генетика. — 2011. — Т. 45, № 4. — С. 41-57. — Бібліогр.: 69 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | The discrepancies arising from conflicting evidence on the results obtained by different laboratories in human gliomas are discussed. Our data highlight the importance of viewing the IGF-related proteins as a complex multifactorial system and show that changes in the expression levels of any one component of the system, in a given malignancy, should be interpreted with caution. As IGF targeting for anticancer therapy is rapidly becoming clinical reality, an understanding of this complexity is very timely. |
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