Synthesis and selectivity of 1-methoxycarbonylmethyl-3-arylamino-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodi- azepin-2-ones binding for CNS benzodiazepine receptors

• Date: 2009
• Main Authors: Burenkova, N.A., Pavlovsky, V.I., Oleinich, I.A., Boyko, I.A., Makan, S.Yu., Artemenko, A.G., Kuz’min, V.E.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2009
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/7369
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Synthesis and selectivity of 1-methoxycarbonylmethyl-3-arylamino-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodi- azepin-2-ones binding for CNS benzodiazepine receptors / N.A. Burenkova, V.I. Pavlovsky, I.A. Oleinich, I.A. Boyko, S.Yu. Makan, A.G. Artemenko, V.E. Kuz’min // Ukrainica Bioorganica Acta. — 2009. — Т. 7, № 1. — С. 8-15. — Бібліогр.: 44 назв. — англ.

Earlier, the methoxycarbonylmethyl fragment at the 1-position and the nitrophenylamine fragment at the 3-position of the 1,4-benzodiazepine ring, on the base of the QSAR analysis of series of 1,4-benzodiazepin-2-one derivatives [1], have been shown to gave compounds with increased affinity for perip...