Application of multiplex PCR with histopathologic features for detection of familial breast cancer in formalin-fixed, paraffin-embedded histologic specimens

• Date: 2008
• Main Authors: Rassi, H., Houshmand, M., Hashemi, M., Majidzadeh, K., Hosseini Akbari, M.H., Shafa Shariat Panahi, M.
• Format: Article
• Language: English
• Published: Інститут клітинної біології та генетичної інженерії НАН України 2008
• Subjects: Оригинальные работы
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/8086
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Application of multiplex PCR with histopathologic features for detection of familial breast cancer in formalin-fixed, paraffin-embedded histologic specimens / H. Rassi, M. Houshmand, M. Hashemi, K. Majidzadeh, M.H. Hosseini Akbari, M. Shafa Shariat Panahi // Цитология и генетика. — 2008. — Т. 42, № 2. — С. 55-62. — Бібліогр.: 31 назв. — англ.

Breast cancer is the most common malignancy among females in the world. Age and familial history are the major risk factors for the development of this disease in Iran. Mutations of BRCA1 and BRCA2 genes are associated with a greatly increased risk for development of familial breast cancer. Frequenc...