Fluorescence intensity profiles of in situ hybridization signals depict genome architecture within human interphase nuclei

• Date: 2008
• Main Authors: Iourov, I.Y., Vorsanova, S.G., Yurov, Y.B.
• Format: Article
• Language: English
• Published: Інститут клітинної біології та генетичної інженерії НАН України 2008
• Subjects: Оригинальные работы
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/8218
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Fluorescence intensity profiles of in situ hybridization signals depict genome architecture within human interphase nuclei / I.Y. Iourov, S.G. Vorsanova, Y.B. Yurov // Цитология и генетика. — 2008. — Т. 42, № 5. — С. 3-8. — Бібліогр.: 20 назв. — англ.

An approach towards construction of two-dimensional (2D) and three-dimensional (3D) profiles of interphase chromatin architecture by quantification of fluorescence in situ hybridization (FISH) signal intensity is proposed. The technique was applied for analysis of signal intensity and distribution w...