Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency
Aim: Due to the common etiologic factor, a considerable number of esophagogastric cancer patients suffer from respiratory insufficiency in course of chronic obstructive pulmonary disease, primary to cancer. Systemic hypoxemia may account for poor oxygenation of tumor tissue-a main driving force of t...
Gespeichert in:
| Datum: | 2007 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2007
|
| Schriftenreihe: | Experimental Oncology |
| Schlagworte: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency / M. Krzystek-Korpacka, M. Matusiewicz, D. Diakowska, K. Grabowski, K. Blachut, I. Kustrzeba-Wojcicka, A. Gamian // Experimental Oncology. — 2007. — Т. 29, № 3. — С. 236–242. — Бібліогр.: 29 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
oai:nasplib.isofts.kiev.ua:123456789-138552 |
|---|---|
| record_format |
dspace |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Krzystek-Korpacka, M. Matusiewicz, M. Diakowska, D. Grabowski, K. Blachut, K. Kustrzeba-Wojcicka, I. Gamian, A. Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency Experimental Oncology |
| description |
Aim: Due to the common etiologic factor, a considerable number of esophagogastric cancer patients suffer from respiratory insufficiency in course of chronic obstructive pulmonary disease, primary to cancer. Systemic hypoxemia may account for poor oxygenation of tumor tissue-a main driving force of tumor neoangiogenesis. We hypothesized that in cancer patients with respiratory insufficiency, systemic hypoxemia may be related to enhanced aggressiveness of cancer on one side and to the elevation of angiogenic factors on the other. Methods: The levels of vascular endothelial growth factors A and C were determined with immunoenzymatic methods in patients diagnosed with esophagogastric cancer with or without co-existing respiratory insufficiency in course of chronic obstructive pulmonary disease and in healthy controls. Blood gasometry and hemoglobin levels of cancer patients were related to cancer histology and TNM status, and to circulating vascular endothelial growth factors A and C. Results: Patients with systemic hypoxemia had higher incidence rates of locally advanced tumors. Partial oxygen pressure and blood oxygen saturation were significantly lowered in patients with T4 cancers as compared to less advanced onces. Circulating vascular endothelial growth factor A, but not C, was more elevated in esophagogastric cancer patients with co-existing respiratory insufficiency, as compared to those without respiratory insufficiency. Vascular endothelial growth factor A was also strongly related to the extension of primary tumor. Conclusion: Our results show that systemic hypoxemia in esophagogastric cancer patients is associated with the extension of primary tumor and that this effect might be mediated by the up-regulation of circulating vascular endothelial growth factor A. |
| format |
Article |
| author |
Krzystek-Korpacka, M. Matusiewicz, M. Diakowska, D. Grabowski, K. Blachut, K. Kustrzeba-Wojcicka, I. Gamian, A. |
| author_facet |
Krzystek-Korpacka, M. Matusiewicz, M. Diakowska, D. Grabowski, K. Blachut, K. Kustrzeba-Wojcicka, I. Gamian, A. |
| author_sort |
Krzystek-Korpacka, M. |
| title |
Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency |
| title_short |
Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency |
| title_full |
Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency |
| title_fullStr |
Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency |
| title_full_unstemmed |
Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency |
| title_sort |
impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors a and c in gastroesophaeal cancer patients with chronic respiratory insufficiency |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2007 |
| topic_facet |
Original contributions |
| citation_txt |
Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency / M. Krzystek-Korpacka, M. Matusiewicz, D. Diakowska, K. Grabowski, K. Blachut, I. Kustrzeba-Wojcicka, A. Gamian // Experimental Oncology. — 2007. — Т. 29, № 3. — С. 236–242. — Бібліогр.: 29 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
AT krzystekkorpackam impactofsystemichypoxemiaoncanceraggressivenessandcirculatingvascularendothelialgrowthfactorsaandcingastroesophaealcancerpatientswithchronicrespiratoryinsufficiency AT matusiewiczm impactofsystemichypoxemiaoncanceraggressivenessandcirculatingvascularendothelialgrowthfactorsaandcingastroesophaealcancerpatientswithchronicrespiratoryinsufficiency AT diakowskad impactofsystemichypoxemiaoncanceraggressivenessandcirculatingvascularendothelialgrowthfactorsaandcingastroesophaealcancerpatientswithchronicrespiratoryinsufficiency AT grabowskik impactofsystemichypoxemiaoncanceraggressivenessandcirculatingvascularendothelialgrowthfactorsaandcingastroesophaealcancerpatientswithchronicrespiratoryinsufficiency AT blachutk impactofsystemichypoxemiaoncanceraggressivenessandcirculatingvascularendothelialgrowthfactorsaandcingastroesophaealcancerpatientswithchronicrespiratoryinsufficiency AT kustrzebawojcickai impactofsystemichypoxemiaoncanceraggressivenessandcirculatingvascularendothelialgrowthfactorsaandcingastroesophaealcancerpatientswithchronicrespiratoryinsufficiency AT gamiana impactofsystemichypoxemiaoncanceraggressivenessandcirculatingvascularendothelialgrowthfactorsaandcingastroesophaealcancerpatientswithchronicrespiratoryinsufficiency AT krzystekkorpackam vliâniesistemnojgipoksemiinaagressivnostʹzabolevaniâisoderžaniecirkuliruûŝihfaktorovrostaéndoteliâsosudovaisubolʹnyhgastroézofagalʹnymrakomshroničeskojrespiratornojnedostatočnostʹû AT matusiewiczm vliâniesistemnojgipoksemiinaagressivnostʹzabolevaniâisoderžaniecirkuliruûŝihfaktorovrostaéndoteliâsosudovaisubolʹnyhgastroézofagalʹnymrakomshroničeskojrespiratornojnedostatočnostʹû AT diakowskad vliâniesistemnojgipoksemiinaagressivnostʹzabolevaniâisoderžaniecirkuliruûŝihfaktorovrostaéndoteliâsosudovaisubolʹnyhgastroézofagalʹnymrakomshroničeskojrespiratornojnedostatočnostʹû AT grabowskik vliâniesistemnojgipoksemiinaagressivnostʹzabolevaniâisoderžaniecirkuliruûŝihfaktorovrostaéndoteliâsosudovaisubolʹnyhgastroézofagalʹnymrakomshroničeskojrespiratornojnedostatočnostʹû AT blachutk vliâniesistemnojgipoksemiinaagressivnostʹzabolevaniâisoderžaniecirkuliruûŝihfaktorovrostaéndoteliâsosudovaisubolʹnyhgastroézofagalʹnymrakomshroničeskojrespiratornojnedostatočnostʹû AT kustrzebawojcickai vliâniesistemnojgipoksemiinaagressivnostʹzabolevaniâisoderžaniecirkuliruûŝihfaktorovrostaéndoteliâsosudovaisubolʹnyhgastroézofagalʹnymrakomshroničeskojrespiratornojnedostatočnostʹû AT gamiana vliâniesistemnojgipoksemiinaagressivnostʹzabolevaniâisoderžaniecirkuliruûŝihfaktorovrostaéndoteliâsosudovaisubolʹnyhgastroézofagalʹnymrakomshroničeskojrespiratornojnedostatočnostʹû |
| first_indexed |
2025-07-31T04:03:04Z |
| last_indexed |
2025-07-31T04:03:04Z |
| _version_ |
1839133711101067264 |
| spelling |
oai:nasplib.isofts.kiev.ua:123456789-1385522025-02-23T17:44:19Z Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency Влияние системной гипоксемии на агрессивность заболевания и содержание циркулирующих факторов роста эндотелия сосудов А и С у больных гастроэзофагальным раком с хронической респираторной недостаточностью Krzystek-Korpacka, M. Matusiewicz, M. Diakowska, D. Grabowski, K. Blachut, K. Kustrzeba-Wojcicka, I. Gamian, A. Original contributions Aim: Due to the common etiologic factor, a considerable number of esophagogastric cancer patients suffer from respiratory insufficiency in course of chronic obstructive pulmonary disease, primary to cancer. Systemic hypoxemia may account for poor oxygenation of tumor tissue-a main driving force of tumor neoangiogenesis. We hypothesized that in cancer patients with respiratory insufficiency, systemic hypoxemia may be related to enhanced aggressiveness of cancer on one side and to the elevation of angiogenic factors on the other. Methods: The levels of vascular endothelial growth factors A and C were determined with immunoenzymatic methods in patients diagnosed with esophagogastric cancer with or without co-existing respiratory insufficiency in course of chronic obstructive pulmonary disease and in healthy controls. Blood gasometry and hemoglobin levels of cancer patients were related to cancer histology and TNM status, and to circulating vascular endothelial growth factors A and C. Results: Patients with systemic hypoxemia had higher incidence rates of locally advanced tumors. Partial oxygen pressure and blood oxygen saturation were significantly lowered in patients with T4 cancers as compared to less advanced onces. Circulating vascular endothelial growth factor A, but not C, was more elevated in esophagogastric cancer patients with co-existing respiratory insufficiency, as compared to those without respiratory insufficiency. Vascular endothelial growth factor A was also strongly related to the extension of primary tumor. Conclusion: Our results show that systemic hypoxemia in esophagogastric cancer patients is associated with the extension of primary tumor and that this effect might be mediated by the up-regulation of circulating vascular endothelial growth factor A. Цель: в связи с общим этиологическим фактором заболевания , значительное количество больных гастроэзофагальным раком страдает от респираторной недостаточности в процессе хронического обструктивного легочного заболевания, кото- рое предшествует раку. Системная гип оксемия может влиять на пониженн ую оксигена цию опухолево й ткани — основной источник опухолевого неоангиогенеза. Авторы предп оложили , что у больных онкологического п рофиля с респираторно й недостаточностью системная гипоксемия может быть связана с повышенной агрессивностью опухолевого процесса, с одной стороны, и повышенным уровнем ангиогенных факторов — с другой. Методы: сод ержание факторов роста эндо- телия сосудов A и C ( VEGF ) опред еляли имму ноферментными мето дами у пациентов с гастроэзофагальным раком на фоне респираторной недостаточности в процессе хронического обструктивного заболевания легких или в отсутствие такового, а также у здоровых доноров. Анализировали д анные газометрии и сод ержания гемоглобина в зависимости от гистологии новообразования, статуса TNM и уровня VEGF A и C. Результаты: у больных с системно й гипоксемие й частота появления новообразований была выше. Парциальное давление кислоро да и насыщение крови кислоро д ом значительно снижено у пациентов с категорией T4. Повышение сод ержания циркулирующего VEGF A, но не C, более выражено у больных с респи- раторной недостаточностью, чем без нее. Содержание VEGF коррелировало с объемом первично й опухоли . Выводы: на результаты показывают, что системная гипоксемия у пациентов с гастроэзофагальным раком связана с увеличением объема первичной опухоли, и такой эффект может быть опосредован повышением содержания циркулирующего VEGF. The authors would like to thank theRegional Center ofBlood Donation and Therapeutics, Wroclaw, Poland for supply of control sera. 2007 Article Impact of systemic hypoxemia on cancer aggressiveness and circulating vascular endothelial growth factors A and C in gastroesophaeal cancer patients with chronic respiratory insufficiency / M. Krzystek-Korpacka, M. Matusiewicz, D. Diakowska, K. Grabowski, K. Blachut, I. Kustrzeba-Wojcicka, A. Gamian // Experimental Oncology. — 2007. — Т. 29, № 3. — С. 236–242. — Бібліогр.: 29 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138552 en Experimental Oncology application/pdf Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |