Дизайн і методологія багатопараметричного фазового картографування мікроскопічних зображень плівок крові щурів у диференціальній діагностиці ступеня важкості сепсису

• Datum: 2026
• Hauptverfasser: Ушенко, О.Г., Дуболазов, О.В., Курек, І.Г., Олар, О.В., Воловик, А.Ю.
• Format: Artikel
• Sprache: Ukrainisch
• Veröffentlicht: Vinnytsia National Technical University 2026
• Schlagworte: фазове картографування; сепсис; поляризаційна мікроскопія; статистичний аналіз; біологічні тканини
• Online Zugang: https://oeipt.vntu.edu.ua/index.php/oeipt/article/view/871
• Назва журналу: Optoelectronic Information-Power Technologies

The paper addresses the problem of differential diagnosis of sepsis severity based on microscopic images of blood films. A multiparametric phase mapping method based on statistical analysis of phase shift distributions is proposed. It is experimentally shown that with increasing pathology severity, the mean and variance decrease, while skewness and kurtosis increase. The results confirm the effectiveness of the method for quantitative assessment of pathological states. The evaluation of the effectiveness of the method showed a high level of differentiation between groups. In particular, for the parameters of asymmetry and kurtosis, excellent diagnostic quality was achieved (over 90% balanced accuracy), while for the mean and variance, good and satisfactory indicators were obtained depending on the groups being compared. This confirms the high informativeness of the statistical parameters of phase maps as diagnostic criteria. The obtained results confirm the effectiveness of the polarization-phase mapping method for objective differential diagnosis of the severity of sepsis and demonstrate its sensitivity to structural changes in biological environments