Калікс[4]арен α-гідроксифосфонові кислоти як потенційні інгібітори протеїнтирозинфосфатаз

• Date: 2014
• Main Authors: Trush, V. V., Tanchuk, V. Yu., Cherenok, S. O., Kalchenko, V. I., Vovk, A. I.
• Format: Article
• Language: English
• Published: National University of Pharmacy 2014
• Subjects: протеїнтирозинфосфатази; інгібітори; каліксарени; докінг; УДК 577.151.4
• Online Access: https://ophcj.nuph.edu.ua/article/view/ophcj.14.782
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

Calix[4]arene are known to be a promising scaffold for designing inhibitors of protein tyrosine phosphatases.In this work calix[4]arene mono- and bis-α-hydroxymethylphosphonic acids have been tested in vitro for the inhibitory activity against some therapeutically important protein tyrosine phosphat...