Гетероциклізації на основі етил 1-арил-4-(бромацетил)-5-метил-1н-піразол- 3-карбоксилатів

• Date: 2013
• Main Authors: Potopnyk, M. A., Matiychuk, V. S., Obushak, M. D.
• Format: Article
• Language: Ukrainian
• Published: National University of Pharmacy 2013
• Subjects: піразол; 1-арилпіразоли; гетероциклізації; тіазол; імідазо[1; 2-a]піридин; імідазо[2; 1-b][1; 3]тіазол; [1; 2; 4]триазоло[3; 4-b][1; 3; 4]тіадіазин; УДК 547.771; 547.781; 547.789; 547.83; 547.876
• Online Access: https://ophcj.nuph.edu.ua/article/view/ophcj.13.756
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

Ethyl 1-aryl-5-methyl-4-(2-R-1,3-thiazol-4-yl)-1H-pyrazole-3-carboxylates, ethyl 1-aryl-4-(imidazo[1,2-a]pyridin-2-yl)-5-methyl-1H-pyrazole-3-carboxylates, ethyl 1-aryl-4-(imidazo[2,1-b][1,3]thiazol-6-yl)-5-methyl-1H-pyrazole-3-carboxylates, ethyl 1-aryl-4-{3-aryl(hetaryl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl}-5-methyl-1H-pyrazole-3-carboxylate have been synthesized by heterocyclisations of ethyl 1-aryl-4-(bromoacetyl)-5-methyl-1H-pyrazole-3-carboxylates with thiobenzamide, 1-(6-methylpyridin-2-yl)thiourea or 1-carbamidoylthiourea, pyridin-2-amine, 1,3-thiazol-2-amine and 4-amino-5-aryl(hetaryl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones, respectively.