Різнолігандні комплекси ренію(i): від флуоресцентних міток до гетеробіметалічних зон- дів з цікавою топологією для подвійної візуалізації

• Date: 2013
• Main Authors: Marty, Louise, François, Alison, Krachko, Tetiana, Galaup, Chantal, Picard, Claude, Amirkhanov, V. M., Benoist, Eric
• Format: Article
• Language: English
• Published: National University of Pharmacy 2013
• Subjects: клік-хімія; різнолігандні комплекси; трис-карбоніл ренію(I); флуоресценція; УДК 547.828.3; 547.791.1; 546.719; 543.426
• Online Access: https://ophcj.nuph.edu.ua/article/view/ophcj.13.773
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

In this paper, five new ternary tricarbonylrhenium(I) complexes based on a pyridinetriazole moiety, the so-called pyta, have been investigated. These cationic complexes of the general formula [Re(CO)3(pyta-COOMe)L] (L = substituted pyridine derivatives) combine a carboxylate functionalization, for further biomolecule conjugation, with a metal chelating site – a pyta-based tricarbonylrhenium moiety – which can act as a fluorescent reporter. The complexes have been prepared using a two-steps pathway involved the activation of [Re(CO)3Cl(bipy)] with triflate silver salts in the presence of acetonitrile followed by the thermally activated substitution of the acetonitrile adduct by commercially available substituted pyridine derivatives. They have been prepared from modest to good yields, fully characterized by means of NMR, IR and mass spectrometry, and their photophysical properties have been investigated. Upon excitation into the MLCT band of each complex (absorption band at ca. 300 nm), three of them exhibit a bright green luminescence centered at c.a. 494 nm, with a quantum yield of 0.60% in acetonitrile. These interesting photophysical features make them potential fluorescent cellular imaging agents. Moreover, thank to their ancillary ligand, they could be also considered as interesting scaffolds for the preparation of dual-imaging heterobimetallic species.