Синтез та антиоксидантні властивості нових тіазоло[4,5-b]піридин-2-онів

• Дата: 2019
• Автори: Chaban, T. I., Matiychuk, Yu. E., Ogurtsov, V. V., Chaban, I. G., Matiychuk, V. S.
• Формат: Стаття
• Мова: Ukrainian
• Опубліковано: National University of Pharmacy 2019
• Теми: органічний синтез; тіазоло[4; 5-b]піридини; антиоксидантна активність; УДК 615.012.1; 547.789.1; органический синтез; тиазоло[4; 5-b]пиридины; антиоксидантная активность; organic synthesis; thiazolo[4; 5-b]pyridines; antioxidant activity; UDC 615.012.1
• Онлайн доступ: https://ophcj.nuph.edu.ua/article/view/ophcj.19.174239
• Назва журналу: Journal of Organic and Pharmaceutical Chemistry

Aim. To expand the synthetic potential of thiazolo[4,5-b]pyridines, study the reactivity and perform the pharmacological screening of the antioxidant activity of the novel compounds synthesized.Results and discussion. A series of novel 3-aryl-5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridine-2-ones were obtained as a result of the interaction of 3-aryl-4-iminothiazolidine-2-ones with ethyl acetoacetate. At this stage the resulting 3-phenyl-5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one was modified in position 5 in the acylation reaction. For all compounds synthesized the primary pharmacological screening of the antioxidant activity was performed; the results showed the potential for the search of antioxidant agents among thiazolo[4,5-b]pyridine-2-ones.Experimental part. By the reactions of [3+3]-cyclocondensation and acylation 12 novel thiazolo[4,5-b]pyridine-2-ones were obtained. The structure of all compounds synthesized was confirmed by the method of 1H NMR-spectroscopy and the data of elemental analysis. The antioxidant activity of the compounds synthesized was investigated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radical.Conclusions. 12 novel thiazolo[4,5-b]pyridines have been synthesized, their antioxidant properties have been investigated, and prospectivity for the search of novel antioxidant agents among thiazolo[4,5-b]pyridines has been shown.