Синтез та взаємодія з альдегідами 4-аміно- 5-(хінолін-2-іл)-4Н-1,2,4-триазол-3-тіолу

• Видавець: National University of Pharmacy
• Дата: 2021
• Автори: Zozulynets, D. М., Kaplaushenko, A. G., Korzhova, A. S.
• Формат: Стаття
• Мова: Ukrainian
• Опубліковано: National University of Pharmacy 2021
• Теми: 5-(хінолін-2-іл)-1; 2; 4-тріазол-3-тіол; 4-метил(арил)іденамінопохідні; кислота хінальдинова; біологічна активність.; 547.79’831.057; 5-(quinolin-2-yl)-1,2,4-triazole-3-thiol; 4-arylidenamino derivatives; quinaldic acid; biological activity
• Онлайн доступ: https://ophcj.nuph.edu.ua/article/view/188137

Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reactionwith aldehydes.Results and discussion. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized, and a number of 4-(ethyl, aryl)idenamino derivatives were obtained on its basis.Experimental part. Using a series of four successive reactions based on quinoline-2-carboxylic acid, 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized; its interaction with aldehydes allowed to obtain a number of 4-(ethyl, aryl)idenamino derivatives. The structure of all compounds synthesized was confrmed by IR and 1H NMR spectroscopy, as well as by elemental analysis, and their purity by thin layer chromatography.Conclusions. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol has been synthesized. It has been found that its interaction with aldehydes leads to the formation of new 4-((ethyl, aryl)idenamino)-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiols.Key words: 5-(quinolin-2-yl)-1,2,4-triazole-3-thiol; 4-arylidenamino derivatives; quinaldic acid; biologicalactivity