N-силілімін трифторопірувату в асиметричному синтезі похідних трифтороаланіну

• Published in: Журнал органічної та фармацевтичної хімії
• Date: 2023
• Volume: 21
• Issue: 2
• Pages: 29-35
• ISSN: 2518-1548
• Author Affiliations: Alona S. Cherednichenko — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Yuliya V. Rassukana — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine
• Main Authors: Cherednichenko, Alona S., Rassukana, Yuliya V.
• Format: Article
• Language: English
• Published: National University of Pharmacy 2023
• Subjects: асиметричний синтез; N-силілімін; реакція Манніха; α-аміно-γ-оксокарбоксилат; трифторометил
• Online Access: https://ophcj.nuph.edu.ua/article/view/284819
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

Aim. To develop a preparative method for the synthesis of N-trimethylsilylimine of trifluoropyruvate, and study its interaction with acetone under organocatalytic conditions.Results and discussion. A simple preparative approach to the first representative of N-silylimines of trifluoropyruvate was de...