Особливості нітрування ароматичних альдегідів, які містять дифлуорометокси-групу
Nitration of aromatic aldehydes with difluoromethoxy group results in the partial ipso-substitution of the aldehyde group if difluoromethoxy group is located in the para-position to the aldehyde group. The presence of a chlorine atom in the meta-position to the aldehyde group increases the contribut...
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| Date: | 2023 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
National University of Pharmacy
2023
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| Subjects: | |
| Online Access: | https://ophcj.nuph.edu.ua/article/view/285469 |
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| Journal Title: | Journal of Organic and Pharmaceutical Chemistry |
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Journal of Organic and Pharmaceutical Chemistry| Summary: | Nitration of aromatic aldehydes with difluoromethoxy group results in the partial ipso-substitution of the aldehyde group if difluoromethoxy group is located in the para-position to the aldehyde group. The presence of a chlorine atom in the meta-position to the aldehyde group increases the contribution of the ipso-substitution, while the presence of a chlorine atom in the ortho-position to the aldehyde group reduces it. The presence of strong donors (alkoxy groups) in the molecule eliminates the contribution of the ipso-substitution. |
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