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Кількісне визначення етонію ферментативним кінетико-спектрофотометричним методом

The use of the cholinesterase enzyme as a component of the analytical system has made it possible to develop a new kinetic-spectrophotometric method, which is alternative to the pharmacopoeial method, for determining the quaternary ammonium salt – ethonium in the substance and a dosage form. This me...

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Veröffentlicht in:Журнал органічної та фармацевтичної хімії
Datum:2024
Jahrgang:22
Heft:1
Сторінки:57-62
ISSN:2518-1548
Автори та афіліації:
  • Mykola Ye. Blazheyevskiy — National University of Pharmacy of the Ministry of Health of Ukraine
  • Olena V. Kovalska — National University of Pharmacy of the Ministry of Health of Ukraine
Hauptverfasser: Blazheyevskiy, Mykola Ye., Kovalska, Olena V.
Format: Artikel
Sprache:Englisch
Veröffentlicht: National University of Pharmacy 2024
Schlagworte:
поверхнево-активні речовини
етоній
холінестераза
ацетилхолін
Online Zugang:https://ophcj.nuph.edu.ua/article/view/304120
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Назва журналу:Journal of Organic and Pharmaceutical Chemistry
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Journal of Organic and Pharmaceutical Chemistry
Beschreibung
Zusammenfassung:The use of the cholinesterase enzyme as a component of the analytical system has made it possible to develop a new kinetic-spectrophotometric method, which is alternative to the pharmacopoeial method, for determining the quaternary ammonium salt – ethonium in the substance and a dosage form. This method is characterized by high sensitivity and specificity, and is relatively cheap. The relative standard deviation of the procedure does not exceed 2.7 %, and the limit of quantification is 17 ng mL–1.
ISSN:2518-1548
DOI:10.24959/ophcj.24.304120

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