Подофілотоксин та арилтетралінові лігнани: методи синтезу кілець A, B, C, D

• Date: 2024
• Main Authors: Flores-Hernández, Francisco, Zárate-López, Tania Isabel, Alcaráz-Cano, Marco Antonio, Escalante, Jaime, Rivera-Ramírez, José Domingo
• Format: Article
• Language: English
• Published: National University of Pharmacy 2024
• Subjects: лігнани; подофілотоксин; арилтетралінові лігнани; етопозид; теніпозид
• Online Access: https://ophcj.nuph.edu.ua/article/view/308942
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

Podophyllotoxin, its derivatives and structural analogues are an extensive group of aryl-tetralin-lignans of interest in pharmacology due to their promising anticancer and antitumor activity. The synthesis methods that have been proposed to date seek to resolve synthetic, stereochemical, pharmacodyn...