O- та N-дифлуорометилювання 2-піридонів дією хлородифлуорометану

Difluoromethylation of various 2-pyridones with the available industrial reagent chlorodifluoromethane (Freon-22) has been studied. Some relationships between the ratio of difluoromethylation products and the reaction conditions, as well as the presence of substituents in the pyridine ring, have bee...

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Bibliographic Details
Date:2024
Main Authors: Petko, Kirill I., Filatov, Andrey A.
Format: Article
Language:English
Published: National University of Pharmacy 2024
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Online Access:https://ophcj.nuph.edu.ua/article/view/312997
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Journal Title:Journal of Organic and Pharmaceutical Chemistry

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Journal of Organic and Pharmaceutical Chemistry
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Summary:Difluoromethylation of various 2-pyridones with the available industrial reagent chlorodifluoromethane (Freon-22) has been studied. Some relationships between the ratio of difluoromethylation products and the reaction conditions, as well as the presence of substituents in the pyridine ring, have been found. The possibility of obtaining difluoromethylation products at the nitrogen atom, in some cases with a preparative yield, has been investigated.