O- та N-дифлуорометилювання 2-піридонів дією хлородифлуорометану
Difluoromethylation of various 2-pyridones with the available industrial reagent chlorodifluoromethane (Freon-22) has been studied. Some relationships between the ratio of difluoromethylation products and the reaction conditions, as well as the presence of substituents in the pyridine ring, have bee...
Збережено в:
| Дата: | 2024 |
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| Автори: | , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
National University of Pharmacy
2024
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| Теми: | |
| Онлайн доступ: | https://ophcj.nuph.edu.ua/article/view/312997 |
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| Назва журналу: | Journal of Organic and Pharmaceutical Chemistry |
Репозитарії
Journal of Organic and Pharmaceutical Chemistry| Резюме: | Difluoromethylation of various 2-pyridones with the available industrial reagent chlorodifluoromethane (Freon-22) has been studied. Some relationships between the ratio of difluoromethylation products and the reaction conditions, as well as the presence of substituents in the pyridine ring, have been found. The possibility of obtaining difluoromethylation products at the nitrogen atom, in some cases with a preparative yield, has been investigated. |
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