O- та N-дифлуорометилювання 2-піридонів дією хлородифлуорометану

• Date: 2024
• Main Authors: Petko, Kirill I., Filatov, Andrey A.
• Format: Article
• Language: English
• Published: National University of Pharmacy 2024
• Subjects: 2-піридони; дифлуорометилювання; хлородифлуорометан
• Online Access: https://ophcj.nuph.edu.ua/article/view/312997
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

Difluoromethylation of various 2-pyridones with the available industrial reagent chlorodifluoromethane (Freon-22) has been studied. Some relationships between the ratio of difluoromethylation products and the reaction conditions, as well as the presence of substituents in the pyridine ring, have bee...