Нові досягнення в асиметричній функціоналізації N-(трет-бутилсульфініл)поліфтороалкілімінів
The review covers the latest achievements in the application of N-(tert-butylsulfinyl)polyfluoroalkyl imines in the asymmetric synthesis and summarizes stereochemical observations of their behavior in different types of reactions (reduction of the C=N bond, addition reactions with organometallic rea...
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| Дата: | 2025 |
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| Автори: | , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
National University of Pharmacy
2025
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| Теми: | |
| Онлайн доступ: | https://ophcj.nuph.edu.ua/article/view/321224 |
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| Назва журналу: | Journal of Organic and Pharmaceutical Chemistry |
Репозитарії
Journal of Organic and Pharmaceutical Chemistry| Резюме: | The review covers the latest achievements in the application of N-(tert-butylsulfinyl)polyfluoroalkyl imines in the asymmetric synthesis and summarizes stereochemical observations of their behavior in different types of reactions (reduction of the C=N bond, addition reactions with organometallic reagents, C-H acids, etc.). Fluorinated N-(tert-butylsulfinyl) imines are convenient substrates for obtaining enantiomerically enriched derivatives of polyfluoroalkyl amines, amino alcohols, amino acids, and heterocyclic systems. In recent decades, various approaches to their functionalization have been proposed. With this in mind, important aspects of their reactivity, regio- and stereochemistry have been systematized in this paper. |
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