Синтез та протизапальна активність деяких нових похідних 6-арил[1,2,4]триазоло[3,4-b][1,3,4]тіадіазолу
A series of 6-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has been synthesized. Their anti-inflammatory activity has been studied in vivo in a carrageenan model of the paw inflammatory edema in rats. 3-(2-Fluorophenyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (3c) and 3-(2-fluo...
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| Datum: | 2024 |
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| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
National University of Pharmacy
2024
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| Schlagworte: | |
| Online Zugang: | https://ophcj.nuph.edu.ua/article/view/321751 |
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| Назва журналу: | Journal of Organic and Pharmaceutical Chemistry |
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Journal of Organic and Pharmaceutical Chemistry| Zusammenfassung: | A series of 6-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has been synthesized. Their anti-inflammatory activity has been studied in vivo in a carrageenan model of the paw inflammatory edema in rats. 3-(2-Fluorophenyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (3c) and 3-(2-fluorophenyl)-6-(4-methoxy-phenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (3d) have been identified as hit compounds with the anti-exudative activity. The crucial role of the fluorine atom in the anti-inflammatory activity has been determined, which value considerably correlates with the calculated values of lipophilicity and solubility. |
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