Балансування фізико-хімічних властивостей між молекулами милосердя (неадиктивними препаратами) і молекулами містицизму (часто адиктивними препаратами)

• Date: 2025
• Main Author: Kraus, Jean-Louis
• Format: Article
• Language: English
• Published: National University of Pharmacy 2025
• Subjects: розробка препаратів для ЦНС; анальгетики; психоактивні препарати; фізико-хімічні властивості; терапевтичні препарати
• Online Access: https://ophcj.nuph.edu.ua/article/view/321860
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

The fundamental physicochemical features of drugs acting on the central nervous system (CNS) determine their ability to penetrate the blood-brain barrier (BBB) and be active against the CNS activities. In this paper, we study two well-known groups of drugs used or prescribed by physicists to treat CNS disorders. One group of drugs belongs to pain killers (the Molecules of Mercy), and the other group belongs to the mind-changers (the Molecules of Mysticism). These two groups of CNS drugs differ in a number of physicochemical parameters: molecular weight, lipophilicity, hydrogen bound acceptor count, hydrogen bond donor count, polar surface area, polarizability, flexibility, bioavailability, and their behavior (agreement or disagreement) related to specific structural conditions, in particular the Lipinski’s rule, Ghose filter, Veber’s rule, Multi-Drug Data Report (MDDR) criteria. In the study of 41 well-known drugs that affect the CNS (both approved or illegal), it has been found that painkillers that do not cause addiction have a physicochemical profile other than those of mind-changer drugs that are very often addictive.  The features of physicochemical parameters associated with the profiles of “pain killer” and “mind-changer” drugs are discussed.