Анелювання 1,2,4-триазинового ядра до 2,3-бензодіазепіну

• Veröffentlicht in: Журнал органічної та фармацевтичної хімії
• Datum: 2025
• Jahrgang: 23
• Heft: 3
• Сторінки: 22-27
• ISSN: 2518-1548
• Автори та афіліації: Natalia M. Bohdan — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Serhii I. Shuvakin — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Diana S. Nechaieva — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Sergii Yu. Suikov — Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences; Serhii L. Bohza — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine
• Hauptverfasser: Bohdan, Natalia M., Shuvakin, Serhii I., Nechaieva, Diana S., Suikov, Sergii Yu., Bohza, Serhii L.
• Format: Artikel
• Sprache: Englisch
• Veröffentlicht: National University of Pharmacy 2025
• Schlagworte: 2,3-бензодіазепін; α-кетоестер; 1,2,4-триазин; анелювання
• Online Zugang: https://ophcj.nuph.edu.ua/article/view/327856
• Назва журналу: Journal of Organic and Pharmaceutical Chemistry

A one-pot, stepwise method for the annelation of the 1,2,4-triazine core to the seven-membered 2,3-benzodiazepine ring via the interaction of the corresponding 2,3-benzodiazepin-1-yl- or 2,3-benzodiazepin-4-ylhydrazines with α-ketoesters has been developed. It has been found that a stepwise formation of an azomethine intermediate followed by solvent replacement and subsequent cyclization enables the desired compounds to be obtained in high yields. Derivatives of a new heterocyclic system of [1,2,4]triazino[3,4-a][2,3]benzodiazepine have been synthesized.