Анелювання 1,2,4-триазинового ядра до 2,3-бензодіазепіну
A one-pot, stepwise method for the annelation of the 1,2,4-triazine core to the seven-membered 2,3-benzodiazepine ring via the interaction of the corresponding 2,3-benzodiazepin-1-yl- or 2,3-benzodiazepin-4-ylhydrazines with α-ketoesters has been developed. It has been found that a stepwise formatio...
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| Datum: | 2025 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
National University of Pharmacy
2025
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| Schlagworte: | |
| Online Zugang: | https://ophcj.nuph.edu.ua/article/view/327856 |
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| Назва журналу: | Journal of Organic and Pharmaceutical Chemistry |
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Journal of Organic and Pharmaceutical Chemistry| Zusammenfassung: | A one-pot, stepwise method for the annelation of the 1,2,4-triazine core to the seven-membered 2,3-benzodiazepine ring via the interaction of the corresponding 2,3-benzodiazepin-1-yl- or 2,3-benzodiazepin-4-ylhydrazines with α-ketoesters has been developed. It has been found that a stepwise formation of an azomethine intermediate followed by solvent replacement and subsequent cyclization enables the desired compounds to be obtained in high yields. Derivatives of a new heterocyclic system of [1,2,4]triazino[3,4-a][2,3]benzodiazepine have been synthesized. |
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