Конкурентне заміщення дифторметокси групи в реакціях амінодегалогенування ароматичних нітросполук
The interaction of substituted nitrobenzenes containing activated halogen atoms (fluorine or chlorine) and the difluoromethoxy group with an aqueous solution of ammonia at high pressure and temperature of 80 - 160 °C was studied. It has been found that under the conditions studied, the difluorometho...
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| Date: | 2025 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
National University of Pharmacy
2025
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| Subjects: | |
| Online Access: | https://ophcj.nuph.edu.ua/article/view/329747 |
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| Journal Title: | Journal of Organic and Pharmaceutical Chemistry |
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Journal of Organic and Pharmaceutical Chemistry| Summary: | The interaction of substituted nitrobenzenes containing activated halogen atoms (fluorine or chlorine) and the difluoromethoxy group with an aqueous solution of ammonia at high pressure and temperature of 80 - 160 °C was studied. It has been found that under the conditions studied, the difluoromethoxy group can be replaced by the amino group as a pseudohalogen. It has been shown that the reactivity of the difluoromethoxy group in the same positions is lower than that of the fluorine atom, but significantly higher than that of the chlorine atom. |
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