Циклічна вольтамперометрія біс(2-нітрофеніл)дисульфідів – попередників бензотіазолів

• Date: 2026
• Main Authors: Puskov, Volodymyr O., Lyapunov, Alexander Yu.
• Format: Article
• Language: English
• Published: National University of Pharmacy 2026
• Subjects: циклічна вольтамперометрія; ароматичні дисульфіди; нітроарени; бензотіазоли; редокс-властивості; вплив замісників
• Online Access: https://ophcj.nuph.edu.ua/article/view/360215
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

Cyclic voltammetry was applied to a series of substituted bis(2-nitrophenyl)disulfides in acetonitrile containing tetraethylammonium tetrafluoroborate under unified experimental conditions. Seven compounds were initially considered (S01-S07). One of them (S07) proved practically insoluble in acetonitrile and was excluded from further analysis. As a result, the electrochemical study was performed for six compounds (S01–S06). Among them, three compounds had voltammograms suitable for semiquantitative treatment, including the comparison of cathodic peak currents, whereas the remaining three compounds provided only qualitative electrochemical information due to their limited solubility and attenuated current response. The multistage cathodic behavior was observed in all cases suitable for analysis. The comparison with nitrobenzene measured under identical conditions indicated a nitro-related reduction process in the region of approximately –1.1 V vs Ag/AgCl and a stronger cathodic process near –1.7 V, which was consistent with the cleavage of the disulfide bond and might overlap with a deeper nitro-related reduction. Substituent effects were evident both in peak potentials and, for the more soluble subset, in the cathodic current value. The results show that cyclic voltammetry is a useful screening tool for substituted aromatic nitrodisulfides, even when the solubility prevents the uniform quantitative comparison across the whole series.