Біологічно активні сполуки кореневищ Iris hungarica

• Datum: 2016
• Hauptverfasser: Mykhailenko, O. O., Kovalyov, V. M., Kovalyov, S. V., Krechun, A. V.
• Format: Artikel
• Sprache: English
• Veröffentlicht: National University of Pharmacy 2016
• Schlagworte: ізофлавоноїди; іригенін; іристекторигенін В; іристекторин В; Iris hungarica; УФ-; ІЧ-; ¹Н ЯМР-; NOESY-спектроскопія; мас-спектрометрія; УДК 615.322; 581.43; 543.42
• Online Zugang: https://ophcj.nuph.edu.ua/article/view/ophcj.16.903
• Назва журналу: Journal of Organic and Pharmaceutical Chemistry

Species of Iris genus (Iridaceae) have a long history of traditional medicinal use in different countries as alternative aperient, tonic, cathartic, diuretic, gall bladder diseases, liver complaints, dropsy, purification of blood, venereal infections, fever, bilious infections and for a variety of heart diseases. The rhizomes of Iris are the rich source of the secondary metabolites, in which flavonoids predominate. The clinical studies of substances from irises gave positive results in the treatment of cancer, bacterial and viral infections. Continuing the search of new biologically active compounds from the plants of Iridaceae family for the first time three isoflavones that are new for this species – irigenin, iristectorigenin B and its glucoside iristectorin B have been isolated from the ethanolic extract of the rhizomes of Iris hungarica Waldst. et Kit., which is widespread in Ukraine. The structure of the compounds is described as 5,7,3’-trihydroxy-6,4’,5’-trimethoxyisoflavone, 5,7,4’-trihydroxy-6,3’-dimethoxyisoflavone and iristectorigenin B-7-O-β-D-glucoside, respectively. The compounds were obtained from the ethyl acetate fraction of the iris rhizomes by column chromatography on silica gel with sequential elution of the chloroform – ethanol solvent with different concentrations. The structure of the compounds has been determined by chemical and spectral methods and in comparison with the literature data.