Криоконсервированные клетки фетальной печени, заключенные в макропористые носители, способствуют восстановлению функций печени после поражения 2-ацетиламинуфлуореном

The effect of cryopreserved fetal liver cells immobilized in macroporous alginate scaffolds on liver injury degree in rats with model of liver failure developed by administration of 2-acetylaminofluorene with subsequent partial hepatectomy. It was shown that immobilized fetal liver cells accelerated...

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Bibliographic Details
Date:2024
Main Authors: Gritsay, D. V., Lebedinskiy, A. S., Ochenashko, O. V., Petrenko, Yu. A.
Format: Article
Language:English
Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2024
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Online Access:https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/101
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Journal Title:Problems of Cryobiology and Cryomedicine

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Problems of Cryobiology and Cryomedicine
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Summary:The effect of cryopreserved fetal liver cells immobilized in macroporous alginate scaffolds on liver injury degree in rats with model of liver failure developed by administration of 2-acetylaminofluorene with subsequent partial hepatectomy. It was shown that immobilized fetal liver cells accelerated recovery of spesific hepatic indices: serum albumin, total bilirubin content, aminotransferase activity. The results of this work indicate the positive effect of fetal liver cells seeded in macroporous scaffolds on course of liver failure and argue the availability of this approach for liver failure treatment.