Особенности проявления модулирующей активности клеток эмбриональной печени на лимфогемопоэтическом комплексе мышей с аутоиммунной гемолитической анемией

• Date: 2006
• Main Authors: Gorskaya, A. Yu., Lutsenko, E. D., Ostankova, L. V., Dubrava, T. G., Goltsev, A. N.
• Format: Article
• Language: English
• Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2006
• Subjects: трансплантація; клітини ембріональної печінки; аутоімунна гемолітична анемія
• Online Access: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1028
• Journal Title: Problems of Cryobiology and Cryomedicine

There were summarised the literature data and the results of own investigations on the evaluation of modulating activity of embryonic liver cells (ELCs) on lymphohemopoietic complex (LHPC) of mice with autoimmune hemolytic anemia (AIHA). The analysis of the degree and character of ELCs effect on both total populations of immune-competent cells (ICCs) in thymus, spleen, bone marrow and peritoneal cavity (PC) and on the spleen and thymus organ-specific stromal elements was performed. The data obtained testify to the fact, that the ELCs application is accompanied with the modification of different degree in structural and morphological characteristics of central and peripheral LHPC organs. In respect of specific manifestations of AIHA (autoantibodies accumulation) the ELCs transplantation contributes to a considerable decrease in their content, that can be characterised as the ELCs therapeutic effect manifestation.