Влияние ПЭГ-1500 на связывание дипиридамола с анионным каналом эритроцитов

Влияние ПЭГ-1500 на связывание дипиридамола с анионным каналом эритроцитов

The authors studied the effect of PEG-1500 on ability of dipyridamole to inhibit the H+ ions transport in erythrocytes. It was established that the inhibitor was not bound in anion channel of erythrocytes ghosts in sulfate medium, despite its ability to block the H+ ions entrance into cells. Using o...

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Bibliographische Detailangaben
Datum:2003
Hauptverfasser: Ramazanov, V. V., Nardid, Ya. O., Olejnik, O. A., Bondarenko, V. A.
Format: Artikel
Sprache:English
Veröffentlicht: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2003
Schlagworte:
еритроцити
аніонний канал
інгібітори транспорту
кріопротектори
Online Zugang:https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1073
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Назва журналу:Problems of Cryobiology and Cryomedicine

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Problems of Cryobiology and Cryomedicine
Beschreibung
Zusammenfassung:The authors studied the effect of PEG-1500 on ability of dipyridamole to inhibit the H+ ions transport in erythrocytes. It was established that the inhibitor was not bound in anion channel of erythrocytes ghosts in sulfate medium, despite its ability to block the H+ ions entrance into cells. Using of fluoride loaded erythrocytes allowed to assume that dipyridamole’s inhibitory ability in cells placed to sulfate medium is controlled by chloride output flow during Jacobs-Stewart cycle functioning, and that proton transport does not reflect the whole amount of entering sulfate. Dipyridamole blockage of stated fraction of H+ ions transport was considerably withdrawn in PEG-1500 presense due to inhibitor’s redistribution from membrane to cryoprotectant solution.

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