Особенности апоптоза, индуцированного снижением температуры

• Видавець: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine
• Дата: 2017
• Автори: Gulevsky, Aleksandr K., Akhatova, Yuliya S., Shchenyavsky, Ivan I.
• Формат: Стаття
• Мова: English
• Опубліковано: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2017
• Теми: apoptosis; hypothermia; cell cultures; apoptosis induction; caspases; oxidative stress; antioxidant system; апоптоз; гипотермия; клеточные культуры; индукция апоптоза; каспазы; окислительный стресс; антиоксидантная система; гіпотермія; клітинні культури; індукція апоптозу; каспази; окислювальний стрес; антиоксидантна система
• Онлайн доступ: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1290

We summarised and analysed here the findings on apoptosis contribution into the cell damages, caused by temperature deviation from the physiological norm (below 37°C). The participation of the caspases, causing the disintegration of anti-apoptotic Bcl-2 family proteins and proteolysis of the DNAase inhibitor, responsible for DNA fragmentation in the apoptosis, induced by a moderate cell cooling, was shown. An important role in cold adaptation mechanism belongs to the RNA-binding protein (cold-inducible RNAbinding protein, CIRP), which is capable to prevent the oxidative stress-induced apoptosis development. We reported here the data, confirming the participation of reactive oxygen species and antioxidant cell components: superoxide dismutase and human peroxiredoxin 1 in apoptosis and cold adaptation.Probl Cryobiol Cryomed 2017; 27(2): 97–109