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Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism
Morphological changes in liver of rats (Rattus norvegicus) and hamsters (Mesocricetus auratus) were studied under artificial (hypoxic-hypercapnic model) (AHM) and natural (hibernation) (NHM) hypometabolism and at the recovery stages (2 and 24 hrs after arousal). The following changes in liver morpho...
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Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine
2017
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Online Access: | https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1292 |
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Problems of Cryobiology and Cryomedicine |
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2020-12-10T19:07:17Z |
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English |
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Ð³Ñ–Ð±ÐµÑ€Ð½Ð°Ñ†Ñ–Ñ ÑˆÑ‚ÑƒÑ‡Ð½Ð¸Ð¹ гіпометаболізм печінка щури хом’Ñки |
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Ð³Ñ–Ð±ÐµÑ€Ð½Ð°Ñ†Ñ–Ñ ÑˆÑ‚ÑƒÑ‡Ð½Ð¸Ð¹ гіпометаболізм печінка щури хом’Ñки Lomako, Viktoriya V. Shilo, Aleksandr V. Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism |
topic_facet |
Ð³Ð¸Ð±ÐµÑ€Ð½Ð°Ñ†Ð¸Ñ Ð¸ÑкуÑÑтвенный гипометаболизм печень крыÑÑ‹ хомÑки Ð³Ñ–Ð±ÐµÑ€Ð½Ð°Ñ†Ñ–Ñ ÑˆÑ‚ÑƒÑ‡Ð½Ð¸Ð¹ гіпометаболізм печінка щури хом’Ñки hibernation artificial hypometabolism liver rats hamsters |
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Article |
author |
Lomako, Viktoriya V. Shilo, Aleksandr V. |
author_facet |
Lomako, Viktoriya V. Shilo, Aleksandr V. |
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Lomako, Viktoriya V. |
title |
Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism |
title_short |
Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism |
title_full |
Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism |
title_fullStr |
Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism |
title_full_unstemmed |
Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism |
title_sort |
morphological changes in liver of homeo- and heterothermic animals under artificial and natural hypometabolism |
title_alt |
Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism МорфологичеÑкие Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² печени гомойо- и гетеротермных животных при иÑкуÑÑтвенном и еÑтеÑтвенном гипометаболизме |
description |
Morphological changes in liver of rats (Rattus norvegicus) and hamsters (Mesocricetus auratus) were studied under artificial (hypoxic-hypercapnic model) (AHM) and natural (hibernation) (NHM) hypometabolism and at the recovery stages (2 and 24 hrs after arousal). The following changes in liver morphology were observed: blood vessel hyperemia and blood thrombus formation (under AHM at all the stages in hamsters and 24 hrs after AHM in rats); the interstitial space expansion (in hamsters under AHM); hepatocytes with nuclei at different stages of necrobiosis (karyopyknosis, karyorrhexis and karyolysis) under NHM, in 2 and 24 hrs after AHM in both species; signs of protein dystrophies of various types and severity degrees (under NHM and AHM in hamsters, and 2 and 24 hrs after AHM in both species); tissue leukocyte infiltration (only in hamsters under AHM, NHM and 24 hrs after NHM); binuclear hepatocytes (in rats at AHM and 24 hrs later, in hamsters under NHM and 24 hrs later). The total protein content in liver was increased under AHM and 24 hrs after AHM in both species, as well as under NHM in hamsters. At these stages either the activation of degenerative and dystrophic processes (decomposition) or the appearance of binuclear hepatocytes (activation of protein synthesis) were observed.Probl Cryobiol Cryomed 2017; 27(2): 121-132 |
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Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine |
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2017 |
url |
https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1292 |
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AT lomakoviktoriyav morphologicalchangesinliverofhomeoandheterothermicanimalsunderartificialandnaturalhypometabolism AT shiloaleksandrv morphologicalchangesinliverofhomeoandheterothermicanimalsunderartificialandnaturalhypometabolism AT lomakoviktoriyav ðœð3⁄4nnð3⁄4ðð3⁄4ð3ðnðμnðoððμððð1⁄4ðμð1⁄2ðμð1⁄2ðnð2ððμnðμð1⁄2ðð3ð3⁄4ð1⁄4ð3⁄4ð1ð3⁄4ðð3ðμnðμnð3⁄4nðμnð1⁄4ð1⁄2nnððð2ð3⁄4nð1⁄2nnðnððnðonƒnnnð2ðμð1⁄2ð1⁄2ð3⁄4 AT shiloaleksandrv ðœð3⁄4nnð3⁄4ðð3⁄4ð3ðnðμnðoððμððð1⁄4ðμð1⁄2ðμð1⁄2ðnð2ððμnðμð1⁄2ðð3ð3⁄4ð1⁄4ð3⁄4ð1ð3⁄4ðð3ðμnðμnð3⁄4nðμnð1⁄4ð1⁄2nnððð2ð3⁄4nð1⁄2nnðnððnðonƒnnnð2ðμð1⁄2ð1⁄2ð3⁄4 |
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2024-09-01T17:51:46Z |
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oai:ojs.pkp.sfu.ca:article-12922020-12-10T19:07:17Z Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism МорфологичеÑкие Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² печени гомойо- и гетеротермных животных при иÑкуÑÑтвенном и еÑтеÑтвенном гипометаболизме Morphological Changes in Liver of Homeo- and Heterothermic Animals Under Artificial and Natural Hypometabolism Lomako, Viktoriya V. Shilo, Aleksandr V. Ð³Ð¸Ð±ÐµÑ€Ð½Ð°Ñ†Ð¸Ñ Ð¸ÑкуÑÑтвенный гипометаболизм печень крыÑÑ‹ хомÑки Ð³Ñ–Ð±ÐµÑ€Ð½Ð°Ñ†Ñ–Ñ ÑˆÑ‚ÑƒÑ‡Ð½Ð¸Ð¹ гіпометаболізм печінка щури хом’Ñки hibernation artificial hypometabolism liver rats hamsters Morphological changes in liver of rats (Rattus norvegicus) and hamsters (Mesocricetus auratus) were studied under artificial (hypoxic-hypercapnic model) (AHM) and natural (hibernation) (NHM) hypometabolism and at the recovery stages (2 and 24 hrs after arousal). The following changes in liver morphology were observed: blood vessel hyperemia and blood thrombus formation (under AHM at all the stages in hamsters and 24 hrs after AHM in rats); the interstitial space expansion (in hamsters under AHM); hepatocytes with nuclei at different stages of necrobiosis (karyopyknosis, karyorrhexis and karyolysis) under NHM, in 2 and 24 hrs after AHM in both species; signs of protein dystrophies of various types and severity degrees (under NHM and AHM in hamsters, and 2 and 24 hrs after AHM in both species); tissue leukocyte infiltration (only in hamsters under AHM, NHM and 24 hrs after NHM); binuclear hepatocytes (in rats at AHM and 24 hrs later, in hamsters under NHM and 24 hrs later). The total protein content in liver was increased under AHM and 24 hrs after AHM in both species, as well as under NHM in hamsters. At these stages either the activation of degenerative and dystrophic processes (decomposition) or the appearance of binuclear hepatocytes (activation of protein synthesis) were observed.Probl Cryobiol Cryomed 2017; 27(2): 121-132 Изучали морфологичеÑкие Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² печени ÐºÑ€Ñ‹Ñ (Rattus norvegicus) и хомÑков (Mesocricetus auratus) при иÑкуÑÑтвенном (гипокÑичеÑки-гиперкапничеÑÐºÐ°Ñ Ð¼Ð¾Ð´ÐµÐ»ÑŒ) (ИГМ) и еÑтеÑтвенном (гибернациÑ) (ЕГМ) гипометаболизме, через 2 и 24 ч поÑле пробуждениÑ. ÐаблюдалиÑÑŒ Ð³Ð¸Ð¿ÐµÑ€ÐµÐ¼Ð¸Ñ ÑоÑудов и тромбы в них (при ИГМ у хомÑков на вÑех ÑтапахнаблюдениÑ, у ÐºÑ€Ñ‹Ñ - через 24 ч); раÑширение интерÑтициальных проÑтранÑтв (у хомÑков при ИГМ); гепатоциты Ñ Ñдрами на разных ÑтадиÑÑ… некробиоза (кариопикноз, кариорекÑÐ¸Ñ Ð¸ кариолизиÑ) (при ЕГМ, через 2 и 24 ч поÑле ИГМ у обоих видов); признаки белковой диÑтрофии разного типа и Ñтепени выраженноÑти (при ЕГМ и ИГМ у хомÑков и через 2 и 24 ч поÑле ИГМ у обоих видов); Ð¸Ð½Ñ„Ð¸Ð»ÑŒÑ‚Ñ€Ð°Ñ†Ð¸Ñ Ñ‚ÐºÐ°Ð½Ð¸ лейкоцитами (только у хомÑков при ИГМ, ЕГМ и через 24 ч поÑле ЕГМ); двуÑдерные гепатоциты (у ÐºÑ€Ñ‹Ñ Ð¿Ñ€Ð¸ ИГМ и через 24 ч, у хомÑков при ЕГМ и через 24 ч). Уровень общего протеина в печени был увеличен при ИГМ и через 24 ч поÑле ИГМ у обоих видов, а также при ЕГМ у хомÑков. Ðа Ñтих Ñтапах наблюдали активацию дегенеративно-диÑтрофичеÑких процеÑÑов (фанероз) или поÑвление двуÑдерных гепатоцитов (Ð°ÐºÑ‚Ð¸Ð²Ð°Ñ†Ð¸Ñ Ñинтеза белка). Вивчали морфологічні зміни в печінці щурів (Rattus norvegicus) Ñ– хом’Ñків (Mesocricetus auratus) при штучному (гіпокÑично-гіперкапнічна модель) (ШГМ) Ñ– природному (гібернаціÑ) (ПГМ) гіпометаболізмі, через 2 Ñ– 24 години піÑÐ»Ñ Ð¿Ñ€Ð¾Ð±ÑƒÐ´Ð¶ÐµÐ½Ð½Ñ. СпоÑтерігалиÑÑ Ð³Ñ–Ð¿ÐµÑ€ÐµÐ¼Ñ–Ñ Ñудин Ñ– тромби в них (при ШГМ у хом’Ñків на вÑÑ–Ñ… етапах ÑпоÑтереженнÑ, у щурів – через 24 години); Ñ€Ð¾Ð·ÑˆÐ¸Ñ€ÐµÐ½Ð½Ñ Ñ–Ð½Ñ‚ÐµÑ€Ñтиціальних проÑторів (у хом’Ñків при ШГМ), гепатоцити з Ñдрами на різних ÑтадіÑÑ… некробіозу (каріопікноз, каріорекÑÐ¸Ñ Ñ– каріолізиÑ) (при ПГМ, через 2 Ñ– 24 години піÑÐ»Ñ Ð¨Ð“Ðœ у обох видів); ознаки білкової диÑтрофії різного типу та ÑÑ‚ÑƒÐ¿ÐµÐ½Ñ Ð²Ð¸Ñ€Ð°Ð·Ð½Ð¾ÑÑ‚Ñ– (при ПГМ Ñ– ШГМ у хом’Ñків та через 2 Ñ– 24 години піÑÐ»Ñ Ð¨Ð“Ðœ у обох видів); Ñ–Ð½Ñ„Ñ–Ð»ÑŒÑ‚Ñ€Ð°Ñ†Ñ–Ñ Ñ‚ÐºÐ°Ð½Ð¸Ð½Ð¸ лейкоцитами (тільки у хом’Ñків: при ШГМ, ПГМ Ñ– через 24 години піÑÐ»Ñ ÐŸÐ“Ðœ); двоÑдерні гепатоцити (у щурів при ШГМ Ñ– через 24 години, у хом’Ñків при ПГМ Ñ– через 24 години). Рівень загального протеїну в печінці був збільшений при ШГМ Ñ– через 24 години піÑÐ»Ñ Ð¨Ð“Ðœ у обох видів, а також при ПГМ у хом’Ñків. Саме на цих етапах ÑпоÑтерігали активацію дегенеративно-диÑтрофічних процеÑів (фанероз) або поÑву двоÑдерних гепатоцитів (Ð°ÐºÑ‚Ð¸Ð²Ð°Ñ†Ñ–Ñ Ñинтезу білка). Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2017-06-25 Article Article Research article application/pdf https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1292 10.15407/cryo27.02.121 Problems of Cryobiology and Cryomedicine; Vol. 27 No. 2 (2017): Probl Cryobiol Cryomed; 121-132 Проблемы криобиологии и криомедицины; Том 27 № 2 (2017): Проблемы криобиологии и криомедицины; 121-132 Проблеми кріобіології і кріомедицини; Том 27 № 2 (2017): Проблеми кріобіології і кріомедицини; 121-132 2518-7376 2307-6143 10.15407/cryo27.02 en https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1292/1376 |