Криоконсервированные экспланты плаценты увеличивают продолжительность жизни мышей-самцов и изменяют показатели выживаемости мышей-самок

• Дата: 2017
• Автори: Prokopyuk, Vladimir Yu., Chub, Oleg V., Shevchenko, Nadezhda A., Falko, Oksana V., Musatova, Irina B., Lazurenko, Victoria V., Tischenko, Aleksandra N., Prokopyuk, Olga S.
• Формат: Стаття
• Мова: English
• Опубліковано: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2017
• Теми: продолжительность жизни; выживаемость; мыши; плацента; криоконсервированные препараты; lifespan; survival; mice; placenta; cryopreserved products; тривалість життя; виживаність; миші; кріоконсервовані препарати
• Онлайн доступ: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1294
• Назва журналу: Problems of Cryobiology and Cryomedicine

According to the WHO data, to date the population lifespan is increasing worldwide due to infant mortality decrease, rather than the duration and life quality of elderly people. Most effective geroprotectors affect the immune and nervous systems, cellcycle, metabolism of carbohydrates, stimulate autophagy. Bioobjects of placental origin possess similar properties. The research aim was to study the effect of cryopreserved human placental explants on lifespan of BALB/c mice. Kaplan-Meier survival curves were analyzed and survival indices were calculated. The differences were determined using the Log-rank test. It has been shown that implantation of cryopreserved placental explants to experimental animals significantly increases the indices in male mice as follows: median of lifespan - by 17.6%; average life expectancy – by 18.1%; 90% survival rate – by 20.8%; maximum lifespan – by 17.9%. The administration of placental explants to female mice did not affect their lifespan, but reduced the probability of death in the reproductive period.Probl Cryobiol Cryomed 2017; 27(2): 143–150