Криоконсервированные экспланты плаценты увеличивают продолжительность жизни мышей-самцов и изменяют показатели выживаемости мышей-самок

Криоконсервированные экспланты плаценты увеличивают продолжительность жизни мышей-самцов и изменяют показатели выживаемости мышей-самок

According to the WHO data, to date the population lifespan is increasing worldwide due to infant mortality decrease, rather than the duration and life quality of elderly people. Most effective geroprotectors affect the immune and nervous systems, cellcycle, metabolism of carbohydrates, stimulate aut...

Повний опис

Збережено в:
Бібліографічні деталі
Видавець:Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine
Дата:2017
Автори: Prokopyuk, Vladimir Yu., Chub, Oleg V., Shevchenko, Nadezhda A., Falko, Oksana V., Musatova, Irina B., Lazurenko, Victoria V., Tischenko, Aleksandra N., Prokopyuk, Olga S.
Формат: Стаття
Мова:English
Опубліковано: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2017
Теми:
продолжительность жизни
выживаемость
мыши
плацента
криоконсервированные препараты
lifespan
survival
mice
placenta
cryopreserved products
тривалість життя
виживаність
миші
кріоконсервовані препарати
Онлайн доступ:https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1294
Теги: Додати тег
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Репозиторії

Problems of Cryobiology and Cryomedicine
Опис
Резюме:According to the WHO data, to date the population lifespan is increasing worldwide due to infant mortality decrease, rather than the duration and life quality of elderly people. Most effective geroprotectors affect the immune and nervous systems, cellcycle, metabolism of carbohydrates, stimulate autophagy. Bioobjects of placental origin possess similar properties. The research aim was to study the effect of cryopreserved human placental explants on lifespan of BALB/c mice. Kaplan-Meier survival curves were analyzed and survival indices were calculated. The differences were determined using the Log-rank test. It has been shown that implantation of cryopreserved placental explants to experimental animals significantly increases the indices in male mice as follows: median of lifespan - by 17.6%; average life expectancy – by 18.1%; 90% survival rate – by 20.8%; maximum lifespan – by 17.9%. The administration of placental explants to female mice did not affect their lifespan, but reduced the probability of death in the reproductive period.Probl Cryobiol Cryomed 2017; 27(2): 143–150

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