Влияние постуральных изменений, постпрандиальной нагрузки, фармакологической денервации и криоденервации n. vagus на вариабельность сердечного ритма у крыс

• Date: 2017
• Main Author: Chizh, Nikolai A.
• Format: Article
• Language: English
• Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2017
• Subjects: варіабельність серцевого ритму; спектральний аналіз; центральний венозний тиск; кріоденервація nervus vagus
• Online Access: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1342
• Journal Title: Problems of Cryobiology and Cryomedicine

Heart rate variability (HRV) spectral analysis was applied to establish how postural change, accompanied by a change in the central venous pressure are associated with a very low-frequency (VLF)-component of the spectrum. Under postprandial load the total power of HRV spectrum was found out to decrease by 1.9 times due to reducing the very low-frequency component of the spectrum. A statistically significant decrease in the LF/HF ratio from 6.7 down to 4.8 due to an increase in the high-frequency range was noted. After treating the animals with Loperamide and Atropine sulfate, which inhibited a motor-evacuation function of gastrointestinal tract, there was established the effect of digestive system on HRV within the LF and HF ranges. The manifestation rate of HRV changes as a result of nervus vagus cryodenervation was shown to be significantly lower than after pharmacological denervation with Atropine sulfate. The ratio of LF/HF components decreased from 3.4 down to 1.3 due to the augmentation of high-frequency component of the spectrum. The findings demonstrated the parasympathetic nervous system to control all the ranges of spectrum and play a major role in HRV formation.Probl Cryobiol Cryomed 2017; 27(3): 266-278