Вплив Ñередовищ, кондиційованих кріоконÑервованими та Ñвіжовиділеними екÑплантами та клітинами плаценти, на органотипові культури маток та Ñєчників мишей
The methods of cell and tissue therapy, the promising objects of those are the placental derivatives, affecting namely female reproductive system and the levels of its regulation, have been widely applied in current reproductive medicine. The mechanisms of this interaction have still remained unclea...
Збережено в:
Дата: | 2018 |
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Автор: | |
Формат: | Стаття |
Мова: | English |
Опубліковано: |
Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine
2018
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Теми: | |
Онлайн доступ: | https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1419 |
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Назва журналу: | Problems of Cryobiology and Cryomedicine |
Репозитарії
Problems of Cryobiology and CryomedicineРезюме: | The methods of cell and tissue therapy, the promising objects of those are the placental derivatives, affecting namely female reproductive system and the levels of its regulation, have been widely applied in current reproductive medicine. The mechanisms of this interaction have still remained unclear. We studied here the influence of the media, conditioned with cryopreserved and freshly-isolated placental cells and explants on isolated murine ovarian, uterine cultures and that of fibroblasts. The cultures were evaluated using morphological methods and metabolic tests. Conditioned media were shown to stimulate metabolic activity of the uterine culture and to suppress it in ovarian culture. No fibroblast response to these media testifies to a direct influence of placental humoral factors on ovarian generative elements and endometrium, but not through the elements of connective tissue. The features of the media, conditioned with the native and cryopreserved placental cells and explants were established as not significantly different.Probl Cryobiol Cryomed 2018; 28(2): 139–150 |
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