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Порівняльна оцінка біологічної активності фракції до 5 кДа з кордової крові великої рогатої худоби після низькотемпературного зберігання (при –80°С) або ліофілізації при лікуванні опікових ран у щурів
Biological activity of the low molecular weight (down to 5 kDa) fraction from cattle cord blood after storage in lyophilized state at 4°C and -80°C in the form of solution in a model of thermal burn of rats' skin was investigated. Actovegin with a pronounced wound healing activity was used as a...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine
2020
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| Subjects: | |
| Online Access: | https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1601 |
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| Summary: | Biological activity of the low molecular weight (down to 5 kDa) fraction from cattle cord blood after storage in lyophilized state at 4°C and -80°C in the form of solution in a model of thermal burn of rats' skin was investigated. Actovegin with a pronounced wound healing activity was used as a comparator drug. The storage of low molecular weight fraction for 3 months under the chosen conditions was found not to reduce its biological activity. Introduced and lyophilized cord blood fraction to experimental animals after simulation of thermal skin burns contributed to a reduced burn wound area, normalization of leukocyte content and phagocytic activity of neutrophils in peripheral blood. The findings enable considering the lyophilization of the low molecular weight fraction followed by storage at 4°C as sensibly more expedient option of storing and transporting the biologically active substance.
Probl Cryobiol Cryomed 2020; 30(1): 47-57 |
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