Вплив кріоекстракту плаценти та блокади ренін-ангіотензин-альдостеронової системи на розвиток ниркової недостатності у щурів

• Date: 2021
• Main Authors: Repin , Mykola, Chyzh , Yuliia, Marchenko, Larysa, Tetyana P. Govorukha, Tetyana P. Govorukha, Brusentsov, Oleksandr
• Format: Article
• Language: English
• Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2021
• Subjects: хронічна ниркова недостатність; кріоекстракт плаценти; медикаментозна блокада ренін-ангіотензин-альдостеронової системи; морфологічна структура; креатинін
• Online Access: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1741
• Journal Title: Problems of Cryobiology and Cryomedicine

Here, we have studied the impact of administration of rat placental cryoextract (PCE), drug blockade of the renin-angiotensin-aldosterone system (RAAS) with enalapril and spironolactone and their combination on the rat kidney tissue structure and excretory function at different stages of chronic renal failure (CRF) development using the glycerol model. In 3 weeks after glycerol introduction, the animals from all the groups showed low values of glomerular filtration rate, impaired blood flow in renal cortex, tubular epithelial dystrophy, inflammation and edema of interstitium, indicating the onset of CRF development. Tubulo-interstitial nephritis and nephrosclerosis were dominated in untreated rats 16 weeks later. The use of RAAS drug blockade, as well as a comprehensive therapy with RAAS blockers and placental cryoextract stopped the inflammatory processes in renal tissue, restored blood circulation and normalized excretory function, which persisted for up to 16 weeks of observation.   Probl Cryobiol Cryomed 2021; 31(3): 223–235