Кардіопротекторна дія низькомолекулярної фракції до 5 кДа кріогемолізату кордової крові корів

• Date: 2022
• Main Authors: Shcheniavsky, Ivan, Kovalenko, Igor, Gulevsky, Oleksandr
• Format: Article
• Language: English
• Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2022
• Subjects: інфаркт міокарда; модель; гіперліпідемія; гіпоксія; низькомолекулярна фракція кордової крові; «Актовегін»
• Online Access: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1806
• Journal Title: Problems of Cryobiology and Cryomedicine

In this report, we have studied a cardioprotective effect of low molecular weight (below 5 kDa) fraction derived from cattle cord blood in a rat model of infarction-like cardiovasopathy. The myocardial infarction development was initiated in the animals, maintained for two months on a diet with excessive intake of fat, calcium and sodium salts, by making hypoxia-hypercapnia in them. The use of this model allowed inducing the infarction-like cardiovasopathy, comparable by many respects with the clinical picture of myocardial infarction, which was confirmed by electrocardiography, enzyme-linked immunosorbent assay and histological analysis. Preliminary administration of low molecular weight (below 5 kDa) fraction of cattle cord blood, as well as Actovegin did not prevent the heart attack, but increased the endurance of rats to hypoxia-hypercapnia and reduced the damage rate to myocardium. A preventive administration of low molecular weight fraction of cord blood was proven to mitigate the risk of hypoxia-induced damages to myocardium.   Probl Cryobiol Cryomed 2022; 32(3):206–213