Особливості термічної деструкції п-аміносаліцилової кислоти в бінарних системах з ?-циклодекстрином
Thermal degradation of para-aminosalicylic acid in binary systems with ?-cyclodextrin has been studied. It was found that destruction of aromatic amino acid in equimolar physical mixture (or ”?-cyclodextrin – para-aminosalicylic acid” inclusion complex of 1:1) begins with decarboxylation reaction. T...
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| Дата: | 2013 |
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| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | Russian |
| Опубліковано: |
Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine
2013
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| Онлайн доступ: | https://www.cpts.com.ua/index.php/cpts/article/view/204 |
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| Назва журналу: | Chemistry, Physics and Technology of Surface |
Репозитарії
Chemistry, Physics and Technology of Surface| Резюме: | Thermal degradation of para-aminosalicylic acid in binary systems with ?-cyclodextrin has been studied. It was found that destruction of aromatic amino acid in equimolar physical mixture (or ”?-cyclodextrin – para-aminosalicylic acid” inclusion complex of 1:1) begins with decarboxylation reaction. Then the oxidative degradation of m-aminophenol and ?-cyclodextrin takes place. Temperatures of para-aminosalicylic acid decarboxylation and oxidative degradation of meta?aminophenol rise from para?aminosalicylic acid and its physical mixture with ?-cyclodextrin to equimolar ”?-cyclodextrin – para-aminosalicylic acid” inclusion complex. It was proved that the increase in thermal stability of the encapsulated para-aminosalicylic acid is mainly due to nonspecific interactions between hydrophobic cavity of cyclic oligosaccharide and aromatic ring of amino acid. |
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