Адсорбція та хімічні перетворення лідокаїну на поверхні високодисперсного кремнезему

It has been found that the highest adsorption of lidocaine on silica surface is observed at рН~8.1 similar to рКа of lidocaine (рК=7.9), that is in a region of рН optimal for realization of maximum biological effect. The interaction of lidocaine with fumed silica surface has been studied by the temp...

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Збережено в:
Бібліографічні деталі
Дата:2010
Автори: Kulyk, T. V., Dudik, O. O., Palyanytsya, B. B., Barvinchenko, V. M.
Формат: Стаття
Мова:Українська
Опубліковано: Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine 2010
Онлайн доступ:https://www.cpts.com.ua/index.php/cpts/article/view/22
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Назва журналу:Chemistry, Physics and Technology of Surface

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Chemistry, Physics and Technology of Surface
Опис
Резюме:It has been found that the highest adsorption of lidocaine on silica surface is observed at рН~8.1 similar to рКа of lidocaine (рК=7.9), that is in a region of рН optimal for realization of maximum biological effect. The interaction of lidocaine with fumed silica surface has been studied by the temperature-programmed desorption mass spectrometry. Maxima for ions with m/z of 171, 147, 131, 130, 121, 116 on the thermal desorption curves have been observed at the temperature of 220-230°C for the lidocaine sample prepared by the equilibrium adsorption procedure from alkaline medium. That is, under these conditions desorption of lidocaine in molecular form takes place as a result of decomposition of adsorption complex between quaternary ammonium salt of lidocaine and silanol group. The kinetic parameters of decomposition (activation energy, order of reaction, pre-exponential factor) of this adsorption complex on silica surface have been calculated.