Адсорбція та хімічні перетворення лідокаїну на поверхні високодисперсного кремнезему
It has been found that the highest adsorption of lidocaine on silica surface is observed at рН~8.1 similar to рКа of lidocaine (рК=7.9), that is in a region of рН optimal for realization of maximum biological effect. The interaction of lidocaine with fumed silica surface has been studied by the temp...
Збережено в:
| Дата: | 2010 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | Українська |
| Опубліковано: |
Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine
2010
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| Онлайн доступ: | https://www.cpts.com.ua/index.php/cpts/article/view/22 |
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| Назва журналу: | Chemistry, Physics and Technology of Surface |
Репозитарії
Chemistry, Physics and Technology of Surface| Резюме: | It has been found that the highest adsorption of lidocaine on silica surface is observed at рН~8.1 similar to рКа of lidocaine (рК=7.9), that is in a region of рН optimal for realization of maximum biological effect. The interaction of lidocaine with fumed silica surface has been studied by the temperature-programmed desorption mass spectrometry. Maxima for ions with m/z of 171, 147, 131, 130, 121, 116 on the thermal desorption curves have been observed at the temperature of 220-230°C for the lidocaine sample prepared by the equilibrium adsorption procedure from alkaline medium. That is, under these conditions desorption of lidocaine in molecular form takes place as a result of decomposition of adsorption complex between quaternary ammonium salt of lidocaine and silanol group. The kinetic parameters of decomposition (activation energy, order of reaction, pre-exponential factor) of this adsorption complex on silica surface have been calculated. |
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