Адсорбція та хімічні перетворення лідокаїну на поверхні високодисперсного кремнезему

• Date: 2010
• Main Authors: Kulyk, T. V., Dudik, O. O., Palyanytsya, B. B., Barvinchenko, V. M.
• Format: Article
• Language: Ukrainian
• Published: Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine 2010
• Online Access: https://www.cpts.com.ua/index.php/cpts/article/view/22
• Journal Title: Chemistry, Physics and Technology of Surface

It has been found that the highest adsorption of lidocaine on silica surface is observed at рН~8.1 similar to рКа of lidocaine (рК=7.9), that is in a region of рН optimal for realization of maximum biological effect. The interaction of lidocaine with fumed silica surface has been studied by the temp...