Возможный механизм коррекции осмотической и температурной чувствительности эритроцитов человека с помощью алкил-β,D-глюкопиранозидов

• Date: 2009
• Main Author: Shpakova, N. M.
• Format: Article
• Language: English
• Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2009
• Subjects: еритроцити людини; гіперосмотичний стрес; холодовий шок; алкіл-β; D- глюкопіранозиди; антигемолітичний ефект; ефективні концентрації
• Online Access: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/234
• Journal Title: Problems of Cryobiology and Cryomedicine

There was studied the effect of glucopyranoside non-ionic derivatives with the alkyl chain length of 6, 8, 10 carbon atoms on hyperosmotic lysis and cold stress development in human erythrocytes. High antihemolytic activity of substances (90–94%) was demonstrated. Efficient concentrations of alkyl glucopyranosides reduce with an increase in alkyl chain length of their molecules. Under cell protection at different lysis types there were calculated the values of ratio of lipid molecule number per 1 molecule of alkyl glucopyranoside in erythrocyte membrane and the membrane concentrations of these substances were established as not significantly differed.