Исследование влияния низкомолекулярных криопротекторов на дыхательную цепь митохондрий методом ЭПР спинового зонда

Исследование влияния низкомолекулярных криопротекторов на дыхательную цепь митохондрий методом ЭПР спинового зонда

Effect of low molecular cryoprotectants, glycerol, 1,2-propane diol and dimethylsulfoxide with concentrations up to 30% on activity of respiratory chain of rat liver mitochondria membranes has been studied by spin probe EPR. It has been established that lowmolecular cryoprotective substances induce...

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Bibliographic Details
Date:2009
Main Author: Nardid, O. A.
Format: Article
Language:English
Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2009
Subjects:
кріопротектори
мітохондрії
електронний парамагнітний резонанс
відновлення спінового зонда
інгібування дихального ланцюга
Online Access:https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/272
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Journal Title:Problems of Cryobiology and Cryomedicine

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Problems of Cryobiology and Cryomedicine
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Summary:Effect of low molecular cryoprotectants, glycerol, 1,2-propane diol and dimethylsulfoxide with concentrations up to 30% on activity of respiratory chain of rat liver mitochondria membranes has been studied by spin probe EPR. It has been established that lowmolecular cryoprotective substances induce inhibition of isolated organelles’ respiratory chain. It has been shown that inhibition rate of spin probe reduction and mitochondria respiration as a part of hepatocytes is lower at the same concentrations, if compared with isolated mitochondria.

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