Біофункціоналізація поверхні магнітокерованих нанокомпозитів имуноглобуліном людини
Methods have been developed of normal human immunoglobuline (Ig) immobilization on the surface of magnetite/polyacrylamide and magnetite/γ-aminopropyltrietoxysilane (Fe3O4/γ-APTES) nanocomposites. The processes of nonspecific adsorption and covalent hemosorption of Ig on the surface of nanocomposite...
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| Datum: | 2008 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | Ukrainisch |
| Veröffentlicht: |
Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine
2008
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| Online Zugang: | https://surfacezbir.com.ua/index.php/surface/article/view/315 |
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| Назва журналу: | Surface |
| Завантажити файл: |  |
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Surface| Zusammenfassung: | Methods have been developed of normal human immunoglobuline (Ig) immobilization on the surface of magnetite/polyacrylamide and magnetite/γ-aminopropyltrietoxysilane (Fe3O4/γ-APTES) nanocomposites.
The processes of nonspecific adsorption and covalent hemosorption of Ig on the surface of nanocomposites mentioned were studied. The isotherms of covalent addition of oxidized Ig were compared with those of non-specific (physical) adsorption of normal human immunoglobuline. Kinetics of Ig releasing into a model environment was studied.
Larger amount of Ig was found to be adsorbed due to covalent addition rather than physical one. Covalent immobilization is more stable to releasing of immunoglobuline into solution. |
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