Lyposome prepfration for directed transportation of drugs
The review is presents the results of the synthesis of liposomes for the targeted drug delivery into the tumor cells. The usage of the definite combination of saturated phospholipids and cholesterol leads to their stability increasing. On using unsaturated phospholipids for liposome preparation one...
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| Date: | 2009 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | Russian |
| Published: |
Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine
2009
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| Online Access: | https://surfacezbir.com.ua/index.php/surface/article/view/343 |
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| Journal Title: | Surface |
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Surface| Summary: | The review is presents the results of the synthesis of liposomes for the targeted drug delivery into the tumor cells. The usage of the definite combination of saturated phospholipids and cholesterol leads to their stability increasing. On using unsaturated phospholipids for liposome preparation one could undertake precautions to minimize oxidation. Depending on the molar ratio of phospholipids and cholesterol, the size of magnetic liposomes is different. The liposomes of lesser diameter are preferable to larger ones because of their ability to escape phagocytosis by the cells of reticuloendothelial system and permeate from the bloodstream into the interstice easily. Among the liposomes, containing polyethylene glycol and antibodies, the most optimal ones are those, which contain the antibodies attached to distal edges of polyethylene glycol molecule chains. The antibody may be attached to polyethylene glycol molecule with the help of thioester or amide bond. In order to obtain sterically stabilized liposomes, water soluble carbodiimide should be taken. |
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