Адсорбція доксорубіцину пірогенним кремнеземом та нанокомпозитами магнетит/силоксан
A technique has been developed for immobilization of the cytostatic drug doxorubicin on the surface of magnetite nanoparticles modified with biocompatible siloxane coating and fumed silica. The processes of adsorption/desorption of doxorubicin at given surfaces were studied, high adsorption activity...
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| Datum: | 2015 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | Ukrainisch |
| Veröffentlicht: |
Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine
2015
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| Schlagworte: | |
| Online Zugang: | https://www.cpts.com.ua/index.php/cpts/article/view/352 |
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| Назва журналу: | Chemistry, Physics and Technology of Surface |
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Chemistry, Physics and Technology of Surface| Zusammenfassung: | A technique has been developed for immobilization of the cytostatic drug doxorubicin on the surface of magnetite nanoparticles modified with biocompatible siloxane coating and fumed silica. The processes of adsorption/desorption of doxorubicin at given surfaces were studied, high adsorption activity of siloxane surface of nanocomposites was determined with respect to doxorubicin. New nanocomposites magnetite/siloxane/doxorubicin synthesized may be promising for use in oncology, in creating the remedies for targeted delivery of drugs and as adsorption materials for intracorporal and extracorporal detoxification of the organism. |
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| DOI: | 10.15407/hftp06.04.481 |